Reducing Oxidative Stress Optimally

From the above groups of agents, a mixture of selected micronutrients containing multiple dietary antioxidants (vitamins A, C and E, beta-carotene and selenium), polyphenolic compounds (curcumin and resveratrol), endogenous antioxidants (alpha-lipoic acid, L-carnitine, and coenzyme Q10), a synthetic antioxidant N-acetylcysteine (NAC), and omega-3-fatty acids is proposed for reducing oxidative stress optimally by enhancing the levels of antioxidant enzymes and phase-2- detoxifying enzymes through activating the Nrf2/ARE pathway, and multiple dietary and endogenous antioxidant chemicals simultaneously. Animal and limited human studies suggest that the proposed micronutrients in the mixture can cross blood-brain barrier at varying levels. This is supported by the observation in which supplementation with individual antioxidants improved neurological symptoms.

Reducing Chronic Inflammation Optimally

Activation of Nrf2 also suppresses inflammation [110, 111]. Some individual antioxidant chemicals from the above groups reduce chronic inflammation [27-34]. Therefore, the proposed mixture of micronutrients for reducing oxidative stress may also decrease chronic inflammation optimally.

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