IBS (Irritable Bowel Syndrome)
IBS (irritable bowel syndrome) is a distressing condition associated with abdominal pain, bloating, and the altered microbiota and the alternate situation of constipation and diarrhea. In industrialized countries, IBS involves from 5% to 20% of the adult population, mainly women and elderly people (Tuomola et al, 2000). In IBS subjects, an altered microbiota composition may be observed, notably Bifidobacteria being present at lower levels than in healthy adults. The pathogenesis of IBS remains unclear, but available evidence suggests that altered gut motility, visceral hypersensitivity, and dysregulation of the brain-gut axis may be important mechanisms (Drossman et al., 2002).
Accumulating clinical evidence links an imbalanced intestinal microbial profile and enteric bacteria mediated mucosal inflammation with IBS. Some probiotics are able to relieve some of the IBS symptoms, such as constipation, flatulence, and bor- borygmi, but their effects and efficacy seem to vary widely among studies and applied strains.