Menu
Home
Log in / Register
 
Home arrow Geography arrow The handbook of biomarkers
Source

Biomarkers of GVHD Following Transplantation of Hematopoietic Cells

Transplantation of hematopoietic cells from unrelated donors can cure blood disorders but carries a significant risk of acute GVHD, which is higher when the recipient and donor are HLA-DPB1 mismatched. The HLA-DPB1 regulatory region variant rs9277534 is associated with HLA-DPB1 expression. A study has shown that the risk of GVHD associated with HLA-DPB1 mismatching was influenced by the HLA-DPB1 rs9277534 expression biomarker (Petersdorf et al. 2015). Among recipients of HLA-DPB1 mismatched transplants from donors with the low- expression allele, recipients with the high-expression allele had a high risk of GVHD.

Plasma Biomarkers of Response to Therapy of GVHD

A study compared 12 biomarkers in plasma obtained a median of 16 d after therapy initiation from patients with a complete response by day 28 after therapy initiation and in plasma obtained from patients with progressive GVHD during therapy (Vander Lugt et al. 2013). The lead biomarker, suppression of tumorigenicity 2 (ST2), had the most significant association with resistance to GVHD therapy and subsequent death without relapse. As compared with patients with low ST2 values at therapy initiation, patients with high ST2 values were 2.3 times as likely to have treatment-resistant GVHD and 3.7 times as likely to die within 6 m after therapy. Patients with low ST2 values had lower mortality without relapse than patients with high ST2 values, regardless of the GVHD grade. Plasma ST2 values at day 14 after transplantation were associated with 6 m mortality without relapse, regardless of the intensity of the conditioning regimen. ST2 levels measured at the initiation of therapy for GVHD and during the first month after transplantation improved risk stratification for treatment-resistant GVHD and death without relapse after transplantation.

 
Source
Found a mistake? Please highlight the word and press Shift + Enter  
< Prev   CONTENTS   Next >
 
Subjects
Accounting
Business & Finance
Communication
Computer Science
Economics
Education
Engineering
Environment
Geography
Health
History
Language & Literature
Law
Management
Marketing
Mathematics
Political science
Philosophy
Psychology
Religion
Sociology
Travel