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SUMMARY

  • • The development of Pulmozyme and Exubera has shown that both local and systemic use of inhaled proteins can be safe and efficacious.
  • • There are a number of opportunities for future success including inhaled antibodies, approaches to address protease-antiprotease imbalances contributing to lung disease, and PEGylated proteins and peptides to improve pharmacokinetics.
  • • Future therapies should concentrate on unmet medical needs and validated targets.
  • • High-efficiency delivery systems are needed with careful consideration of aerosol properties for reproducible delivery to the lung with high deposition efficiency in the alveolar region.
  • • Cost needs to be considered. Advances in protein manufacture and biosimilars to reduce cost will help.

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