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Home arrow Health arrow Cognitive impairment and dementia in Parkinson disease
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Conclusion

Dementia is common in PD, especially as the disease progresses and patients get older. In its pure form, dementia in PD occurs when LB pathology spreads to involve cortical and limbic structures. In addition, many PD-D patients have concurrent AD or vascular changes. Clinicians will observe slightly different cognitive features in the different pathological forms that occur across the PD-D spectrum. The regional distribution of pathology will correlate with symptoms. For example, patients with ‘pure PD-D’ solely associated with LB pathology are less likely to experience a primarily amnestic dementia. When amnesia is a prominent feature, concurrent AD pathology is likely, beginning in medial temporal lobe regions that are key for forming new memories. Overall, there is clinical and pathological heterogeneity amongst PD-D patients. With an eye toward aetiologically based treatments, it will become more important to identify the biological factors involved in the development of dementia in each PD patient.

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