Future trends and conclusion

Plants extracts include a wide range of compounds with potential application in ruminants feeding. In particular essential oils, tannins and saponins have been proven to display mechanisms that modify the rumen fermentation and improve animal production. This mostly includes more efficient use of dietary protein and energy and decreased methane emissions, which sometimes result in increased milk yield or liveweight gain. However, despite extensive research conducted in the last decades, the use of plant extracts as feed additives in ruminant livestock is still limited by several factors. In addition to those related to highly variable composition and dosage used, the lack of robust in vivo studies that confirm the outcomes observed in vitro is one of the main barriers. Transferring the dosage used in vitro to in vivo conditions is challenging, but without such studies the implementation of a supplementary successful strategy at farm level is not possible. Another important factor to consider is the duration of the in vivo tests. While many treatments (i.e. saponins) failed to have persistent effects, others (i.e. essential oils) need a longer time of exposure to achieve a sustained improvement in productivity.

Future research needs to strength the collaboration between animal feed companies, including those developing and providing additives with plant extracts, and scientists to make use of existing on-farm data and to better understand the effect of plant extracts on animal health and performance.

References

Abarghuei, M., Rouzbehan, Y. and Alipour, D. 2011. Effect of oak (Quercus libani Oliv.) leave tannin on ruminal fermentation of sheep. Journal of Agricultural Science and Technology 13, 1021 -32.

Aboagye, I. A., Oba, M., Castillo, A. R., Koenig, К. M., Iwaasa, A. D. and Beauchemin, K. A. 2018. Effects of hydrolyzable tannin with or without condensed tannin on methane emissions, nitrogen use, and performance of beef cattle fed a high-forage diet. Journal of Animal Science 96(12), 5276-86. doi:10.1093/jas/sky352.

Aboagye, I. A., Oba, M., Koenig, К. M., Zhao, G. Y. and Beauchemin, K. A. 2019. Use of gallic acid and hydrolyzable tannins to reduce methane emission and nitrogen excretion in beef cattle fed a diet containing alfalfa silage. Journal of Animal Science 97(5), 2230-44. doi: 10.1093/jas/skz 101.

Acamovic, T. and Brooker, J. D. 2005. Biochemistry of plant secondary metabolites and their effects in animals. Proceedings of the Nutrition Society 64(3), 403-12. doi: 10.1079/pns2005449.

Aguerre, M. J., Capozzolo, M. C„ Lencioni, P„ Cabral, C. and Wattiaux, M. A. 2016. Effect of quebracho-chestnut tannin extracts at 2 dietary crude protein levels on performance, rumen fermentation, and nitrogen partitioning in dairy cows. Journal of Dairy Science 99(6), 4476-86. doi:10.3168/jds.2015-10745.

Anantasook, N., Wanapat, M., Cherdthong, A. and Gunun, P. 2015. Effect of tannins and saponins in Samanea saman on rumen environment, milk yield and milk composition in lactating dairy cows. Journal of Animal Physiology and Animal Nutrition 99(2), 335-44. doi:10.1111/jpn. 12198.

Animut, G., Puchala, R., Goetsch, A. L„ Patra, A. K., Sahlu, T„ Varel, V. H. and Wells, J. 2008a. Methane emission by goats consuming diets with different levels of condensed tannins from lespedeza. Animal Feed Science and Technology 144(3-4), 212-27. doi:10.1016/j.anifeedsci.2007.10.014.

Animut, G„ Puchala, R„ Goetsch, A. L., Patra, A. K., Sahlu, T., Varel, V. H. and Wells, J. 2008b. Methane emission by goats consuming different sources of condensed tannins. Animal Feed Science and Technology 144(3-4), 228-41. doi: 10.1016/j. anifeedsci.2007.10.015.

Anitescu, G., Doneanu, C. and Radulescu, V. 1997. Isolation of coriander oil: comparison between steam distillation and supercritical CO, extraction. Flavour and Fragrance Journal 12(3), 173-6. doi: 10.1002/(SICI)1099-1026( 199705)12:3<173::AID-FFJ63 0>3.0.CO;2-1.

Barry, T. N. and Manley, T. R. 1984. The role of condensed tannins in the nutritional value of Lotus pedunculatus for sheep: 2. Quantitative digestion of carbohydrates and proteins. British Journal of Nutrition 51(3), 493-504. doi: 10.1079/bjn 19840055.

Beauchemin, K. A. and McGinn, S, M. 2006. Methane emissions from beef cattle: effects of fumaric acid, essential oil, and canola oil. Journal of Animal Science 84(6), 1489-96. doi:10.2527/2006.8461489x.

Belanche, A., Abecia, L., Holtrop, G., Guada, J. A., Castrillo, C., De la Fuente, G. and Balcells, J. 2011. Study of the effect of presence or absence of protozoa on rumen fermentation and microbial protein contribution to the chyme. Journal of Animal Science 89(12), 4163-74 doi: 10.2527/jas.2010-3703.

Belanche, A., De la Fuente, G., Moorby, J. M. and Newbold, C. J. 2012a. Bacterial protein degradation by different rumen protozoal groups. Journal of Animal Science 90(12), 4495-504. doi:10.2527/jas.2012-5118.

Belanche, A., Doreau, M., Edwards, J. E., Moorby, J. M., Pinloche, E. and Newbold, C. J. 2012b. Shifts in the rumen microbiota due to the type of carbohydrate and level of protein ingested by dairy cattle are associated with changes in rumen fermentation. Journal of Nutrition 142(9), 1684-92. doi:10.3945/jn.112.159574.

Belanche, A., de la Fuente, G. and Newbold, C. J. 2015. Effect of progressive inoculation of fauna-free sheep with holotrich protozoa and total-fauna on rumen fermentation, microbial diversity and methane emissions. FEMS Microbiology Ecology 91(3), 1-10. doi:10.1093/femsec/fiu026.

Belanche, A., Pinloche, E., Preskett, D. and Newbold, C. J. 2016. Effects and mode of action of chitosan and ivy fruit saponins on the microbiome, fermentation and methanogenesis in the rumen simulation technique. FEMS Microbiology Ecology 92(1), 1-13. doi: 10.1093/femsec/fiv160.

Belanche, A., Newbold, C., Morgavi, D., Bach, A., Zweifel, B. and Yanez-Ruiz, D. 2019. A meta-analysis describing the effects of a commercial essential oils blend on performance, digestion and methane emissions in dairy cows. Animals (in press).

Benchaar, C. and Greathead, FI. 2011. Essential oils and opportunities to mitigate enteric methane emissions from ruminants. Animal Feed Science and Technology 166-167, 338-55. doi:10.1016/j.anifeedsci.2011.04.024.

Benchaar, C., Petit, H. V., Berthiaume, R., Ouellet, D. R., Chiquette, J. and Chouinard, P. Y. 2007. Effects of essential oils on digestion, ruminal fermentation, rumen microbial populations, milk production, and milk composition in dairy cows fed alfalfa silage or corn silage. Journal of Dairy Science 90(2), 886-97. doi:10.3168/jds. S0022-0302(07)71572-2.

Benchaar, C., Calsamiglia, S., Chaves, A. V., Fraser, G. R., Colombatto, D., McAllister, T. A. and Beauchemin, K. A. 2008. A review of plant-derived essential oils in ruminant nutrition and production. Animal Feed Science and Technology 145(1-4), 209-28. doi:10.1016/j.anifeedsci.2007.04.014.

Benchaar, C., Lettat, A., Hassanat, F„ Yang, W. Z., Forster, R. J., Petit, H. V. and Chouinard, P. Y. 2012. Eugenol for dairy cows fed low or high concentrate diets: effects on digestion, ruminal fermentation characteristics, rumen microbial populations and milk fatty acid profile. Animal Feed Science and Technology 178(3-4), 139-50. doi:10.1016/j.anifeedsci.2012.10.005.

Bhat, T. K., Singh, B. and Sharma, О. P. 1998. Microbial degradation of tannins-a current perspective. Biodegradation 9(5), 343-57. doi:10.1023/a:1008397506963.

Bhatta, R., Enishi, O., Yabumoto, Y., Nonaka, l„ Takusari, N., FHiguchi, K. and Takenaka, A. M. Kurihara, M. 2012. Methane reduction and energy partitioning in goats fed two concentrations of tannin from Mimosa spp. J. Agric. Sci, 84,409-415..

Blanch, M., Carro, M. D., Ranilla, M. J„ Viso, A., Vazquez-Anon, M. and Bach, A. 2016. Influence of a mixture of cinnamaldehyde and garlic oil on rumen fermentation, feeding behaviour and performance of lactating dairy cows. Animal Feed Science and Technology 219, 313-23. doi:10.1016/j.anifeedsci.2016.07.002.

Bodas, R., Lopez, S„ Fernandez, M., Garci'a-Gonzalez, R., Rodriguez, A. B., Wallace, R. J. and Gonzalez, J. S. 2008. In vitro screening of the potential of numerous plant species as antimethanogenicfeed additives for ruminants. Animal Feed Science and Technology 145(1-4), 245-58. doi:10.1016/j.amfeedsci.2007.04.015.

Bodas, R., Prieto, N., Garci'a-Gonzalez, R., Andres, S., Giraldez, F. J. and Lopez, S. 2012. Manipulation of rumen fermentation and methane production with plant secondary metabolites. Animal Feed Science and Technology 176(1-4), 78-93. doi: 10.1016/j. anifeedsci.2012.07.010.

Braun, H. S., Schrapers, К. T., Mahlkow-Nerge, K., Stumpff, F. and Rosendahl, J. 2019. Dietary supplementation of essential oils in dairy cows: evidence for stimulatory effects on nutrient absorption. Animal: an International Journal of Animal Bioscience 13(3), 518-23. doi: 10.1017/S1751731118001696.

Broderick, G. A., Uden, P, Murphy, M. L. and Lapins, A. 2004. Sources of variation in rates of in vitro ruminal protein degradation. Journal of Dairy Science 87(5), 1345-59. doi: 10.3168/jds.S0022-0302(04)73284-1.

Burt, S. 2004. Essential oils: their antibacterial properties and potential applications in foods-а review. International Journal of Food Microbiology 94(3), 223-53. doi: 10.1016/j.ijfoodmicro.2004.03.022.

Busquet, M.,Calsamiglia, S., Ferret, A. and Kamel, C. 2005a. Screening forthe effects of natural plant extracts and secondary plant metabolites on rumen microbial fermentation in continuous culture. Animal Feed Science and Technology 123, 597-613.

Busquet, M., Calsamiglia, S„ Ferret, A., Cardozo, P. W. and Kamel, C. 2005b. Effects of cinnamaldehyde and garlic oil on rumen microbial fermentation in a dual flow continuous culture. Journal of Dairy Science 88(7), 2508-16. doi:10.3168/jds. S0022-0302(05)72928-3.

Calsamiglia, S., Busquet, M., Cardozo, P. W., Castillejos, L. and Ferret, A. 2007. Invited review: essential oils as modifiers of rumen microbial fermentation. Journal of Dairy Science 90(6), 2580-95. doi: 10.3168/jds.2006-644.

Canaes.T. S„ Zanferari, F., Maganhe, B. L.,Takiya, C.S., Silva, T. H., Del Valle, T. A. and Renno, F. P. 2017. Increasing dietary levels of citral oil on nutrient total tract digestibility, ruminal fermentation, and milk composition in Saanen goats .Animal Feed Science and Technology 229, 47-56. doi: 10.1016/j.anifeedsci.2017.05.002.

Canul-Solis, J. R„ Pineiro-Vazquez, A. T„ Briceno-Poot, E. G., Chay-Canul, A. J., Alayon- Gamboa, J. A., Ayala-Burgos, A. J., Aguilar-Perez, C. F., Solorio-Sanchez, F. J., Castelan-Ortega, O. A. and Ku-Vera, J. C. 2014. Effect of supplementation with saponins from Yucca schidigera on ruminal methane production by Pelibuey sheep fed Pennisetum purpureum grass. Animal Production Science 54(10), 1834-7. doi: 10.1071/AN 14296.

Cardozo, P. W„ Calsamiglia, S„ Ferret, A. and Kamel, C. 2004. Effects of natural plant extracts on ruminal protein degradation and fermentation profiles in continuous culture. Journal of Animal Science 82(11), 3230-6. doi: 10.2527/2004.82113230x.

Cardozo, P. W., Calsamiglia, S., Ferret, A. and Kamel, C. 2005. Screening for the effects of natural plant extracts at different pH on in vitro rumen microbial fermentation of a high-concentrate diet for beef cattle. Journal of Animal Science 83(11), 2572-9. doi : 10.2527/2005.83112572x.

Cardozo, P. W„ Calsamiglia, S., Ferret, A. and Kamel, C. 2006. Effects of alfalfa extract, anise, capsicum, and a mixture of cinnamaldehyde and eugenol on ruminal fermentation and protein degradation in beef heifers fed a high-concentrate diet. Journal of Animal Science 84(10), 2801-8. doi: 10.2527/jas.2005-593.

Carson, C. F., Мее, B. J. and Riley, T. V. 2002. Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage, and salt tolerance assays and electron microscopy. Antimicrobial Agents and Chemotherapy 46(6), 1914-20. doi: 10.1128/aac.46.6.1914-1920. 2002.

Castro-Montoya, J., Peiren, N., Cone, J. W., Zweifel, B., Fievez, V. and De Campeneere, S. 2015. In vivo and in vitro effects of a blend of essential oils on rumen methane mitigation. Livestock Science 180, 134-42. doi: 10.1016/j.livsci.2015.08.010.

Chaves, A. V., Dugan, M. E. R., Stanford, K„ Gibson, L. L., Bystrom, J. M., McAllister, T. A., Van Herk, F. and Benchaar, C. 2011. A dose-response of cinnamaldehyde supplementation on intake, ruminal fermentation, blood metabolites, growth performance, and carcass characteristics of growing lambs. Livestock Science 141 (2-3), 213-20. doi:10.1016/j.livsci.2011.06.006.

Chiquette, J., Cheng, K.-J., Costerton, J. W. and Milligan, L. P. 1988. Effect of tannins on the digestibility of two isosynthetic strains of birdsfoot trefoil (Lotus corniculatus L.) using in vitro and in sacco techniques. Canadian Journal of Animal Science 68(3), 751-60. doi:10.4141/cjas88-084.

Cieslak, A., Zmora, P„ Pers-Kamczyc, E. and Szumacher-Strabel, M. 2012. Effects of tannins source (Vaccinium vitis idaea L.)on rumen microbial fermentation in vivo. Animal Feed Science and Technology 176(1-4), 102-6. doi:10.1016/j.anifeedsci.2012.07.012.

Cieslak, A., Szumacher-Strabel, M., Stochmal, A. and Oleszek, W. 2013. Plant components with specific activities against rumen methanogens. Animal: an International Journal of Animal Bioscience 7(Suppl. 2), 253-65. doi: 10.1017/S1751731113000852.

Cobellis, G„ Trabalza-Marinucci, M. and Yu, Z. 2016. Critical evaluation of essential oils as rumen modifiers in ruminant nutrition: a review. Science of the Total Environment 545-546, 556-68. doi: 10.1016/j.scitotenv.2015.12.103.

Cowan, M. M. 1999. Plant products as antimicrobial agents. Clinical Microbiology Reviews 12(4), 564-82. doi:10.1128/CMR.12.4.564.

de Jesus, F„ Del Valle, E. T. A., Calomeni, G. D., Silva, T. H., Takiya, C. S„ Vendramini, T. FI. A., Paiva, P. G., Silva, G. G., Netto, A. S. and Renno, F. P. 2013. Influence of a blend of functional oils or monensin onnutrient intake and digestibility, ruminal fermentation andmilk production of dairy cows .Animal Feed Science and Technology 219, 59-67.

Delaquis, P. J., Stanich, K„ Girard, B. and Mazza, G. 2002. Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils. International Journal of Food Microbiology 74(1-2), 101-9. doi:10.1016/ s0168-1605(01 )00734-6.

Dentinho, M. T. P, Belo, A. T. and Bessa, R. J. B. 2014. Digestion, ruminal fermentation and microbial nitrogen supply in sheep fed soybean meal treated with Cistus ladanifer L. tannins. Small Ruminant Research 119(1-3), 57-64. doi: 10.1016/j. smallrumres.2014.02.012.

Denyer, S. P. and Hugo, W. B. 1991. Biocide-induced damage to the bacterial cytoplasmic membrane, In: Denyer, S. P. and Hugo, W. B. (Eds), Mechanisms of Action of Chemical Biocides. Blackwell Scientific Publications, Oxford, UK, pp, 171-88.

Dhama, K., Latheef, S, K., Mam, S., Samad, H. A., Karthik, K., Tiwari, R., Khan, R. U., Alagawany, M., Farag, M. R„ Alam, G. M„ Laudadio, V. and Tufarelli, V, 2015. Multiple beneficial applications and modes of action of herbs in poultry health and production: a review. International Journal of Pharmacology 11(3), 152-76. doi: 10.3923/ijp.2015.152.176.

Dickhoefer, U„ Ahnert, S. and Susenbeth, A. 2016. Effects of quebracho tannin extract on rumen fermentation and yield and composition of microbial mass in heifers. Journal of Animal Science 94(4), 1561-75. doi:10.2527/jas.2015-0061.

Doce, R. R., Belenguer, A., Toral, P. G., Hervas, G. and Frutos, P. 2013. Effect of the administration of young leaves of Quercus pyrenaica on rumen fermentation in relation to oak tannin toxicosis in cattle. Journal of Animal Physiology and Animal Nutrition 97(1), 48-57. doi:10.1111/j. 1439-0396.2011.01241 .x.

Dschaak, С. M., Williams, С. M., Holt, M. S„ Eun, J. S., Young, A. J. and Min, B. R. 2011. Effects of supplementing condensed tannin extract on intake, digestion, ruminal fermentation, and milk production of lactating dairy cows. Journal of Dairy Science 94(5), 2508-19. doi: 10.3168/jds.2010-3818.

Durmic, Z., Moate, P. J., Eckard, R., Revell, D. K., Williams, R. and Vercoe, P. E. 2014. In vitro screening of selected feed additives, plant essential oils and plant extracts for rumen methane mitigation. Journal of the Science of Food and Agriculture 94(6), 1191-6. doi: 10.1002/jsfa.6396.

Elcoso, G., Zweifel, B. and Bach, A. 2019. Effects of a blend of essential oils on milk yield and feed efficiency of lactating dairy cows. Applied Animal Science 35(3), 304-11. doi: 10.15232/aas.2018-01825.

Eschenlauer, S. С. P„ McKain, N.. Walker, N. D., McEwan, N. R., Newbold, C. J. and Wallace, R. J. 2002. Ammonia production by ruminal microorganisms and enumeration, isolation, and characterization of bacteria capable of growth on peptides and amino acids from the sheep rumen. Applied and Environmental Microbiology 68(10), 4925- SI . doi:10.1128/aem.68.10.4925-4931.2002.

Estelle, R. E. 2010. Coping with shrub secondary metabolites by ruminants. Small Ruminant Research 94(1-3), 1-9. doi:10.1016/j.smallrumres.2010.09.012.

Eugene, M., Archimede, H. and Sauvant, D. 2004. Quantitative meta-analysis on the effects of defaunation of the rumen on growth, intake and digestion in ruminants. Livestock Production Science 85(1), 81-97. doi:10.1016/S0301-6226(03)00117-9.

Evans, J. D. and Martin, S. A. 2000. Effects of thymol on ruminal microorganisms. Current Microbiology 41 (5), 336-40. doi: 10.1007/s002840010145.

Finlay, B. J., Esteban, G., Clarke, K. J., Williams, A. G., Embley, T. M. and Hirt, R. P. 1994. Some rumen ciliates have endosymbiotic methanogens. FEMS Microbiology Letters 117(2), 157-61. doi:10.1111/j.1574-6968.1994.tb06758.x.

Firkins, J. L„ Yu, Z. and Morrison, M. 2007. Ruminal nitrogen metabolism: perspectives for integration of microbiology and nutrition for dairy. Journal of Dairy Science 90(Suppl. 1), E1-16. doi: 10.3168/jds.2006-518.

Flores, A. J., Garciarena, A. D., Vieyra, J. M. H., Beauchemin, K. A. and Colombatto, D. (2013). Effects of specific essential oil compounds on the ruminal environment, milk production and milk composition of lactating dairy cows at pasture. Animal feed science and technology, 186(1-2), 20-26.

Focant, M., Froidmont, E., Archambeau, Q„ Dang Van, Q, C, and Larondelle, Y. 2019. The effect of oak tannin (Quercus robur) and hops (Humulus lupulus) on dietary nitrogen efficiency, methane emission, and milk fatty acid composition of dairy cows fed a low-protein diet including linseed. Journal of Dairy Science 102(2), 1144-59. doi: 10.3168/jds.2018-15479.

Fraisse, D., Carnat, A., Viala, D., Pradel, P., Besle, J. M., Coulon, J. B., Felgines, C. and Lamaison, J. L. 2007. Polyphenolic composition of a permanent pasture: variations related to the period of harvesting. Journal of the Science of Food and Agriculture 87(13), 2427-35. doi:10.1002/jsfa.2918.

Francis, G., Kerem, Z., Makkar, H. P. and Becker, K. 2002.The biological action of saponins in animal systems: a review. British Journal of Nutrition 88(6), 587-605. doi: 10.1079/ BJN2002725.

Franz, C. and Novak, J. 2009. Sources of essential oils. In: Ba§er, К. H. C. and Buchbauer, G. (Eds), Handbook of Essential Oils: Science, Technology, and Applications. CRC Press, Boca Raton, FL, pp. 48-90.

Frutos, P, Plervas, G.,Giraldez, F. J.and Mantecon.A. R.2004. Review. Tannins and ruminant nutrition. Spanish Journal of Agricultural Research 2(2), 191-202. doi: 10.5424/ sjar/2004022-73.

Ganguly, S. 2013. Plerbal and plant derived natural products as growth promoting nutritional supplements for poultry birds: a review. Journal of Pharmaceutical and Scientific Innovation 2(3), 12-3. doi:10.7897/2277-4572.02323.

Garcia-Gonzalez, R., Lopez, S., Fernandez, M., Bodas, R. and Gonzalez, J.S. 2008. Screening the activity of plants and spices for decreasing ruminal methane production in vitro. Animal Feed Science and Technology 147(1-3), 36-52. doi:10.1016/j. anifeedsci.2007.09.008.

Ghizzi, L. G., Del Valle, T. A., Takiya, C. S„ da Silva, G. G„ Zilio, E. M. C., Grigoletto, N. T. S., Martello, L. S. and Renno, F. P. 2018. Effects of functional oils on ruminal fermentation, rectal temperature, and performance of dairy cows under high temperature humidity index environment. Animal Feed Science and Technology 246, 158-66. doi: 10.1016/j. anifeedsci.2018.10.009.

Giannenas,!., Skoufos, J., Giannakopoulos, C., Wiemann, M., Gortzi, O., Lalas, S.and Kyriazakis, I. 2011. Effects of essential oils on milk production, milk composition, and rumen microbiota in Chios dairy ewes. Journal of Dairy Science 94(11), 5569-77. doi: 10.3168/jds.2010-4096.

Gill, M., Smith, P. and Wilkinson, J. M. 2010. Mitigating climate change: the role of domestic livestock. Animal: an International Journal of Animal Bioscience 4(3), 323- 33. doi:10.1017/S1751731109004662.

Goel, G., Makkar, H. P. S. and Becker, K. 2008. Effects of Sesbania sesban and Carduus pycnocephalus leaves and Fenugreek (Trigonella foenum-graecum L.) seeds and their extracts on partitioning of nutrients from roughage-and concentrate- based feeds to methane. Animal Feed Science and Technology 147(1-3), 72-89. doi: 10.1016/j. anifeedsci.2007.09.010.

Grainger, C, Clarke, T., Auldist, M. J., Beauchemin, K. A., McGinn, S. M., Waghorn, G. C. and Eckard, R. J. 2009. Potential use of Acacia mearnsii condensed tannins to reduce methane emissions and nitrogen excretion from grazing dairy cows. Canadian Journal of Animal Science 89(2), 241-51. doi: 10.4141/CJAS08110.

Greathead, H. 2003. Plants and plant extracts for improving animal productivity. Proceedings of the Nutrition Society 62(2), 279-90. doi:10.1079/pns2002197.

Gunun, P., Wanapat, M., Gunun, N„ Cherdthong, A., Sirilaophaisan, S. and Kaewwongsa, W. 2016. Effects of condensed tannins in mao (Antidesma thwaitesianum Muell. Arg.) seed meal on rumen fermentation characteristics and nitrogen utilization in goats. Asian-Australasian Journal of Animal Sciences 29(8), 1111-9. doi: 10.5713/ ajas.15.0552.

Guo, Y. Q., Liu, J. X., Lu, Y., Zhu, W. Y„ Denman, S. E. and McSweeney, C. S. (2008). Effect of tea saponin on methanogenesis, microbial community structure and expression of mcrA gene, in cultures of rumen micro-organisms. Letters in Applied Microbiology, 47(5), 421-426..

Guyader, J„ Eugene, M., Doreau, M., Morgavi, D. P„ Gerard, C., Loncke, C. and Martin, C. 2015. Nitrate but not tea saponin feed additives decreased enteric methane emissions in nonlactating cows. Journal of Animal Science 93(11), 5367-77. doi: 10.2527/jas.2015-9367.

Hagerman, A. and Butler, L. G. 1991. Tannins and lignins. In: Rosenthal, G. A. and Berenbaum, M. R. (Eds), Herbivores: Their Interactions with Secondary Plant Metabolites (vol. 1), pp. 355-88.

Harborne, J. B. and Baxter, H. 1999. The Handbook of Natural Flavonoids (vols. 1 and 2). John Wiley and Sons, Hoboken, NJ.

Hart, K. J., Yanez-Ruiz, D. R., Duval, S. M., McEwan, N. R. and Newbold, C. J. 2008. Plant extracts to manipulate rumen fermentation. Animal Feed Science and Technology 147(1-3), 8-35. doi:10.1016/j.anifeedsci.2007.09.007.

Hart, K. J., Jones, H. G., Waddams, К. E., Worgan, H. J., Zweifel, B. and Newbold, C. J. 2019. An essential oil blend decreases methane emissions and increases milk yield in dairy cows. Open Journal of Animal Sciences 09(3), 259-67. doi: 10.4236/ ojas.2019.93022.

Hatew, B., Cone, J. W., Pellikaan, W. F., Podesta, S. C., Bannink, A., Hendriks, W. H. and Dijkstra, J. 2015. Relationship between in vitro and in vivo methane production measured simultaneously with different dietary starch sources and starch levels in dairy cattle. Animal Feed Science and Technology 202, 20-31. doi: 10.1016/j. anifeedsci.2015.01.012.

Hess, H. D., Kreuzer, M., Dfaz,T. E., Lascano, С. E„ Carulla, J. E„ Soliva, C. R. and Machmuller, A. 2003. Saponin rich tropical fruits affect fermentation and methanogenesis in faunated and defaunated rumen fluid. Animal Feed Science and Technology 109(1- 4), 79-94. doi: 10.1016/S0377-8401 (03)00212-8.

Holtshausen, L„ Chaves, A. V., Beauchemin, K. A., McGinn, S. M., McAllister, T. A., Odongo, N. E., Cheeke, P. R. and Benchaar, C. 2009. Feeding saponin-containing Yucca schidigera and Quillaja saponaria to decrease enteric methane production in dairy cows. Journal of Dairy Science 92(6), 2809-21. doi:10.3168/jds.2008-1843.

lason, G. R., Hartley, S. E. and Duncan, A. J. 1993. Chemical composition of Calluna vulgaris (Ericaceae): do responses to fertilizer vary with phenological stage? Biochemical Systematics and Ecology 21(3), 315-21. doi:10.1016/0305-1978(93)90023-K.

Jadhav, R. V., Kannan, A., Bhar, R„ Sharma, O. P„ Bhat,T. K., Gulati, A., Rajkumar, K., Sharma, R., Mai, G., Singh, B. and Sharma, V. K. 2017. Effect of tea (Camellia sinensis) seed saponin supplementation on growth performance, nutrient utilization, microbial protein synthesis and hemato-biochemical attributes of gaddi goats. Animal Nutrition and Feed Technology 17(2), 255-68. doi: 10.5958/0974-181 X.2017.00025.7.

Jayanegara, A., Leiber, F. and Kreuzer, M. 2012. Meta-analysis of the relationship between dietary tannin level and methane formation in ruminants from in vivo and in vitro

experiments. Journal of Animal Physiology and Animal Nutrition 96(3), 365-75. doi:10.1111/j. 1439-0396.2011.01172.x.

Jones, G. A., McAllister, T. A., Muir, A. D. and Cheng, K. J. 1994. Effects of saifoin (Onobrychis viciifolia Scop.) condensed tannins on growth and proteolysis by 4 strains of ruminal bacteria. Applied and Environmental Microbiology 60(4), 1374-8. doi:10.1128/AEM.60.4.1374-1378.1994.

Jouany, J. P. and Morgavi, D. P. 2007. Use of 'natural' products as alternatives to antibiotic feed additives in ruminant production. Animal: an International Journal of Animal Bioscience 1(10), 1443-66. doi:10.1017/S1751731107000742.

Junior, F. P., Cassiano, E. C. O., Martins, M. F., Romero, L. A., Zapata, D. С. V., Pinedo, L. A., Marino, С. T. and Rodrigues, P. H. M. 2017. Effect of tannins-rich extract from Acacia mearnsii or monensin as feed additives on ruminal fermentation efficiency in cattle. Livestock Science 203, 21-9. doi: 10.1016/j.livsci.2017.06.009.

Kholifa, A. E., Matloupa, О. H., Morsy, T. A., Abdo, M. M., Abu Elella, A. A., Anele, U. Y. and Swanson, К. C. 2017. Rosemary and lemongrass herbs as phytogenic feed additives to improve efficient feed utilization, manipulate rumen fermentation and elevate milk production of Damascus goats. Livestock Science 204, 39-46. doi: 10.1016/j. Iivsci.2017.08.001.

Khorrami, B., Vakili, A. R., Mesgaran, M. D. and Klevenhusen, F. 2015. Thyme and cinnamon essential oils: potential alternatives for monensin as a rumen modifier in beef production systems. Animal Feed Science and Technology 200, 8-16. doi: 10.1016/j. anifeedsci.2014.11.009.

Klita, P. T., Mathison, G. W., Fenton, T. W. and Hardin, R. T. 1996. Effects of alfalfa root saponins on digestive function in sheep. Journal of Animal Science 74(5), 1144-56. doi:10.2527/1996.7451144x.

Klop, G., Dijkstra, J., Dieho, K„ Hendriks, W. H. and Bannink, A. 2017. Enteric methane production in lactating dairy cows with continuous feeding of essential oils or rotational feeding of essential oils and lauric acid. Journal of Dairy Science 100(5), 3563-75. doi: 10.3168/jds.2016-12033.

Knobloch, K., Weis, N. and Weigand, H. 1986. Mechanism of antimicrobial activity of essential oils. Planta Medica 52(6), 556-. doi:10.1055/s-2007-969370.

Knobloch, K., Pauli, A., Iberl, B., Weigand, H. and Weis, N. 1989. Antibacterial and antifungal properties of essential oil components. Journal of Essential Oil Research 1(3), 119-28. doi:10.1080/10412905.1989.9697767.

Koenig, К. M. and Beauchemin, K. A. 2018. Effect of feeding condensed tannins in high protein finishing diets containing corn distillers grains on ruminal fermentation, nutrient digestibility, and route of nitrogen excretion in beef cattle. Journal of Animal Science 96(10), 4398-413. doi:10.1093/jas/sky273.

Koenig, К. M., Beauchemin, K. A. and McGinn, S. M. 2018. Feeding condensed tannins to mitigate ammonia emissions from beef feed lot cattle fed high-protein finishing diets containing distillers grains. Journal of Animal Science 96(10), 4414-30. doi: 10.1093/ jas/sky274.

Kroon, P. A. and Williamson, G. 1999. Hydroxycinnamates in plants and food: current and future perspectives. Journal of the Science of Food and Agriculture 79(3), 355-61. doi: 10.1002/(SICI)1097-0010(19990301 )79:3<355::AID-JSFA255>3.0.CO;2-G.

Krueger, W. K., Gutierrez-Banuelos, H., Carstens, G. E., Min, B. R., Pinchak, W. E., Gomez, R. R., Anderson, R. C., Krueger, N. A. and Forbes, T. D. A. 2010. Effects of dietary tannin source on performance, feed efficiency, ruminal fermentation, and carcass and non-carcass traits in steers fed a high-grain diet. Animal Feed Science and Technology 159(1-2), 1-9. doi:10.1016/j.amfeedsci.2010.05.003.

Lee, S. E„ Hwang, H. J„ Ha, J. S„ Jeong, H. S. and Kim, J. H. 2003. Screening of medicinal plant extracts for antioxidant activity. Life Sciences 73(2), 167-79. doi: 10.1016/ s0024-3205(03)00259-5.

Leinmuller, E., Steingass, H. and Menke, K. 1991. Tannins in ruminant feedstuffs. In: Bittner, A. (Ed.), Animal Research and Development (vol. 33). Institut fur WissenschaftlicheZusammenarbeit, Germany, pp. 9-62.

Lima, P. R., Apdini, T., Freire, A. S., Santana, A. S., Moura, L. M. L., Nascimento, J. C. S., Rodrigues, R. T. S., Dijkstra, J., Garcez Neto, A. F., Queiroz, M. A. A. and Menezes, D. R. 2019. Dietary supplementation with tannin and soybean oil on intake, digestibility, feeding behavior, ruminal protozoa and methane emission in sheep. Animal Feed Science and Technology 249, 10-7. doi: 10.1016/j.anifeedsci.2019.01.017.

Liu, H.,Vaddella,V. and Zhou, D. 2011. Effects of chestnut tannins and coconut oil on growth performance, methane emission, ruminal fermentation, and microbial populations in sheep. Journal of Dairy Science 94(12), 6069-77. doi:10.3168/jds.2011-4508.

Makkar, H. P. S.2003. Effects and fate of tannins in ruminant animals, adaptation to tannins, and strategies to overcome detrimental effects of feeding tannin-rich feeds. Small Ruminant Research 49(3), 241 -56. doi: 10.1016/S0921 -4488(03)00142-1.

Malik, P, Singhal, K. and Deshpande, S. 2009. Effect of saponin rich lucerne fodder supplementation on rumen fermentation, bacterial and protozoal population in buffalo bulls. Indian Journal of Animal Sciences 79, 912-6.

Malik, P. K„ Kolte, A. P„ Baruah, L., Saravanan, M., Bakshi, B. and Bhatta, R. 2017. Enteric methane mitigation in sheep through leaves of selected tanniniferous tropical tree species. Livestock Science 200, 29-34. doi:10.1016/j.livsci.2017.04.001.

Mangan, J. L. 1988. Nutritional effects of tannins in animal feeds. Nutrition Research Reviews 1(1), 209-31. doi:10.1079/NRR19880015.

Mao, H.-L., Wang, J.-K., Zhou, Y.-Y. and Liu, J.-X. 2010. Effects of addition of tea saponins and soybean oil on methane production, fermentation and microbial population in the rumen of growing lambs. Livestock Science 129(1-3), 56-62. doi: 10.1016/j. livsci.2009.12.011.

Martinez, S„ Madrid, J., Hernandez, F., Megias, M. D„ Sotomayor, J. A. and Jordan, M. J. 2006. Effect of thyme essential oils (Thymus hyemalis and Thymus zygis) and monensin on in vitro ruminal degradation and volatile fatty acid production. Journal of Agricultural and Food Chemistry 54(18), 6598-602. doi:10.1021/jf060985p.

McAllister, T. A., Bae, H. D., Jones, G. A. and Cheng, K. J. 1994. Microbial attachment and feed digestion in the rumen. Journal of Animal Science 72(11), 3004-18. doi:10.25 27/1994.72113004x.

McIntosh, F. M., Williams, P, Losa, R., Wallace, R. J., Beever, D. A. and Newbold, C. J. 2003. Effects of essential oils on ruminal microorganisms and their protein metabolism. Applied and Environmental Microbiology 69(8), 5011 -4. doi: 10.1128/ aem.69.8.5011-5014.2003.

McSweeney, C. S„ Palmer, B., Bunch, R. and Krause, D. O. 2001a. Effect of the tropical forage calliandra on microbial protein synthesis and ecology in the rumen. Journal of Applied Microbiology 90(1), 78-88. doi:10.1046/J.1365-2672.2001.01220.x.

McSweeney, C. S., Palmer, B„ McNeill, D. M.and Krause, D.0.2001 b. Microbial interactions with tannins: nutritional consequences for ruminants. Animal Feed Science and Technology 91(1-2), 83-93. doi: 10.1016/S0377-8401 (01 )00232-2.

Min, B. R. and Solaiman, S. 2018. Comparative aspects of plant tannins on digestive physiology, nutrition and microbial community changes in sheep and goats: a review. Journal of Animal Physiology and Animal Nutrition 102(5), 1181-93. doi: 10.1111/ jpn.12938.

Min, B. R., Barry, T. N., Attwood, G. T. and McNabb, W. C. 2003. The effect of condensed tannins on the nutrition and health of ruminants fed fresh temperate forages: a review. Animal Feed Science and Technology 106(1-4), 3-19. doi:10.1016/ S0377-8401 (03)00041-5.

Molina-Botero, I. C, Arroyave-Jaramillo, J., Valencia-Salazar, S„ Barahona-Rosales, R., Aguilar-Perez, C. F., Burgos, A. A., Arango, J. and Ku-Vera, J. C. 2019. Effects of tannins and saponins contained in foliage of Gliricidia sepium and pods of Enterolobium cyclocarpum on fermentation, methane emissions and rumen microbial population in crossbred heifers. Animal Feed Science and Technology 251, 1-11. doi:10.1016/j. anifeedsci.2019.01.011.

Morgavi, D. P., Forano, E., Martin, C. and Newbold, C. J. 2010. Microbial ecosystem and methanogenesis in ruminants. Animal: an International Journal of Animal Bioscience 4(7), 1024-36. doi: 10.1017/S1751731110000546.

Morrissey, J. P. and Osbourn, A. E. 1999. Fungal resistance to plant antibiotics as a mechanism of pathogenesis. Microbiology and Molecular Biology Reviews: MMBR 63(3), 708-24. doi: 10.1128/MMBR.63.3.708-724.1999.

Mueller-Flarvey, I. 2006. Unravelling the conundrum of tannins in animal nutrition and health. Journal of the Science of Food and Agriculture 86(13), 2010-37. doi: 10.1002/ jsfa.2577.

Muthusamy, N. and Sankar, V. 2015. Phytogenic compounds used as a feed additives in poultry production. International Journal of Science Environment and Technology 4, 167-71.

Nagy, J. G., Steinhoff, H. W. and Ward, G. M. 1964. Effects of essential oils of sagebrush on deer rumen microbial function. Journal of Wildlife Management 28(4), 785-90. doi: 10.2307/3798795.

Newbold, C. J., El Flassan, S. M., Wang, J., Ortega, M. E. and Wallace, R. J. 1997. Influence of foliage from African multipurpose trees on activity of rumen protozoa and bacteria. British Journal of Nutrition 78(2), 237-49. doi:10.1079/bjn19970143.

Newbold, C. J., de la Fuente, G., Belanche, A., Ramos-Morales, E. and McEwan, N. R. 2015. The role of ciliate protozoa in the rumen. Frontiers in Microbiology 6, 1313. doi:10.3389/fmicb.2015.01313.

Oh, FI. K„ Jones, M. B. and Longhurst, W. M. 1968. Comparison of rumen microbial inhibition resulting from various essential oils isolated from relatively unpalatable plant species. Applied Environmental Microbiology 16(1), 39-44. doi: 10.1128/ AEM.16.1.39-44.1968.

Okoh, O. O., Sadimenko, A. P. and Afolayan, A. J. 2010. Comparative evaluation of the antibacterial activities of the essential oils of Rosmarinus officinalis L. obtained by hydrodistillation and solvent free microwave extraction methods. Food Chemistry 120( 1), 308-12. doi: 10.1016/j.foodchem.2009.09.084.

Ornaghi, M. G„ Passetti, R. A. C., Torrecilhas, J. A., Mottin, C„ Vital, A. С. P, Guerrero, A., Sanudo, C„ del Mar Campo, M. and Prado, I. N. 2017. Essential oils in the diet of young bulls: effect on animal performance, digestibility, temperament, feeding behaviour and carcass characteristics. Animal Feed Science and Technology 234, 274-83. doi: 10.1016/j.anifeedsci.2017.10.008.

Pathak, A. K., Dutta, N., Pattanaik, A. K., Chaturvedi, V. B. and Sharma, K. 2017. Effect of condensed tannins from Ficus infectoria and Psidium guajava leaf meal mixture on nutrient metabolism, methane emission and performance of lambs. Asian- Australasian Journal of Animal Sciences 30(12), 1702-10. doi:10.5713/ajas.17.0060.

Patra, A. K. 2010. Meta-analyses of effects of phytochemicals on digestibility and rumen fermentation characteristics associated with methanogenesis. Journal of the Science of Food and Agriculture 90(15), 2700-8. doi: 10.1002/jsfa.4143.

Patra, A. K. 2011. Effects of essential oils on rumen fermentation, microbial ecology and ruminant production. Asian Journal of Animal and Veterinary Advances 6(5), 416-28. doi: 10.3923/ajava.2011.416.428.

Patra, A. K. and Saxena, J. 2009a. Dietary phytochemicals as rumen modifiers: a review of the effects on microbial populations. Antonie Van Leeuwenhoek 96(4), 363-75. doi: 10.1007/s10482-009-9364-1.

Patra, A. K. and Saxena, J. 2009b. The effect and mode of action of saponins on the microbial populations and fermentation in the rumen and ruminant production. Nutrition Research Reviews 22(2), 204-19. doi: 10.1017/S0954422409990163.

Patra, A. K. and Saxena, J. 2011. Exploitation of dietary tannins to improve rumen metabolism and ruminant nutrition. Journal of the Science of Food and Agriculture 91(1), 24-37. doi:10.1002/jsfa.4152.

Patra, A. K. and Yu, Z. 2012. Effects of essential oils on methane production and fermentation by, and abundance and diversity of, rumen microbial populations. Applied and Environmental Microbiology 78(12), 4271-80. doi:10.1128/ AEM.00309-12.

Patra, A. K. and Yu, Z. 2013. Effects of coconut and fish oils on ruminal methanogenesis, fermentation, and abundance and diversity of microbial populations in vitro. Journal of Dairy Science 96(3), 1782-92. doi:10.3168/jds.2012-6159.

Patra, A. K. and Yu, Z. 2015. Essential oils affect populations of some rumen bacteria in vitro as revealed by microarray (RumenBactArray) analysis. Frontiers in Microbiology 6, 297. doi:10.3389/fmicb.2015.00297.

Patra, A., Park, T., Kim, M. and Yu, Z. 2017. Rumen methanogens and mitigation of methane emission by anti-methanogenic compounds and substances. Journal of Animal Science and Biotechnology 8,13. doi: 10.1186/s40104-017-0145-9.

Pauli, A. and Schilcher, H. 2010. In vitro antimicrobial activities of essential oils monographed in the European pharmacopoeia 6th edition. In: Ba§er, К. H. C. and Buchbauer, G. (Eds), ffandbook of Essential Oils: Science, Technology, and Applications. CRC Press, Boca Raton, FL, pp. 343-548.

Pen, B., Sar, C., Mwenya, B., Kuwaki, K., Morikawa, R. and Takahashi, J. 2006. Effects of Yucca schidigera and Quillaja saponaria extracts on in vitro ruminal fermentation and methane emission. Animal Feed Science and Technology 129(3-4), 175-86. doi: 10.1016/j.anifeedsci.2006.01.002.

Perevolotsky, A. 1994. Tannins in Mediterranean woodland species: lack of response to browsing and thinning. Oikos 71(2), 333-40. doi: 10.2307/3546282.

Pineiro-Vazquez, A. T., Canul-Solis, J. R., Casanova-Lugo, F., Chay-Canul, A. J., Ayala- Burgos, A. J., Solorio-Sanchez, F. J., Aguilar-Perez, C. F. and Ku-Vera, J. C. 2017. Emision de metano en ovinos alimentados con Pennisetum purpureum у arboles que contienen taninos condensados. Revista mexicana de ciencias pecuarias 8(2), 111 -9. doi: 10.22319/rmcp.v8i2.4401.

Pineiro-Vazquez, A. T., Canul-Solis, J. R., Jimenez-Ferrer, G. O., Alayon-Gamboa, J. A., Chay-Canul, A. J., Ayala-Burgos, A. J., Aguilar-Perez, C. F. and Ku-Vera, J. C. 2018. Effect of condensed tannins from Leucaena leucocephala on rumen fermentation, methane production and population of rumen protozoa in heifers fed low-quality forag e.Asian-Australasian Journal of Animal Sciences 31(11), 1738-46. doi: 10.5713/ ajas.17.0192.

Popova, M., Guyader, J., Silberberg, M., Seradj, A. R., Saro, C„ Bernard, A., Gerard, C., Martin, C. and Morgavi, D. P. 2019. Changes in the rumen microbiota of cows in response to dietary supplementation with nitrate, linseed, and saponin alone or in combination. Applied and Environmental Microbiology 85(4), e02657-02618. doi:10.1128/AEM.02657-18.

Poungchompu, O., Wanapat, M., Wachirapakorn, C., Wanapat, S. and Cherdthong, A. 2009. Manipulation of ruminal fermentation and methane production by dietary saponins and tannins from mangosteen peel and soapberry fruit. Archives of Animal Nutrition 63(5), 389-400. doi:10.1080/17450390903020406.

Ramfrez-Restrepo, C. A., O'Neill, C. J., Lopez-Villalobos, N„ Padmanabha, J., Wang, J. K. and McSweeney, C. 2016a. Effects of tea seed saponin supplementation on physiological changes associated with blood methane concentration in tropical Brahman cattle. Animal Production Science 56(3), 457-65. doi:10.1071/AN15582.

Ramfrez-Restrepo, C. A.,Tan, C„ O'Neill, C. J., Lopez-Villalobos, N., Padmanabha, J., Wang, J. and McSweeney, C. S. 2016b. Methane production, fermentation characteristics, and microbial profiles in the rumen of tropical cattle fed tea seed saponin supplementation. Animal Feed Science and Technology 216, 58-67. doi: 10.1016/j. anifeedsci.2016.03.005.

Ramos-Morales, E., De La Fuente, G., Duval, S„ Wehrli, C., Bouillon, M., Lahmann, M., Preskett, D., Braganca, R. and Newbold, C. J. 2017. Antiprotozoal effect of saponins in the rumen can be enhanced by chemical modifications in their structure. Frontiers in Microbiology 8, 399. doi:10.3389/fmicb.2017.00399.

Rhoades, D. F. 1985. Offensive-defensive interactions between herbivores and plants: their relevance in herbivore population dynamics and ecological theory. American Naturalist 125(2), 205-38. doi:10.1086/284338.

Rira, M., Morgavi, D. P, Archimede, H., Marie-Magdeleine, C„ Popova, M., Bousseboua, H. and Doreau, M. 2015. Potential of tannin-rich plants for modulating ruminal microbes and ruminal fermentation in sheep. Journal of Animal Science 93(1), 334- 47. doi:10.2527/jas.2014-7961.

Russell, J. B. 1991. Intracellular pH of acid-tolerant ruminal bacteria. Applied and Environmental Microbiology 57(11), 3383-4. doi: 10.1128/AEM.57.11.3383-3384.1991.

Russell, J. B. and Rychlik, J. L. 2001. Factors that alter rumen microbial ecology. Science 292(5519), 1119-22. doi:10.1126/science.1058830.

Russell, J. B., Onodera, R. and Hino, T. 1991. Ruminal protein fermentation: new perspectives on previous contradictions. In: Tsuda, T., Sasaki, Y. and Kawashima, R. (Eds), Physiological Aspects of Digestion and Metabolism in Ruminants. Academic Press Limited, London, UK, pp. 691-7.

Salami, S. A., Valenti, B., Bella, M., O'Grady, M. N.. Luciano, G., Kerry, J. P, Jones, E., Priolo, A. and Newbold, C. J. 2018. Characterisation of the ruminal fermentation and microbiome in lambs supplemented with hydrolysable and condensed tannins. FEMS Microbiology Ecology 94(5), fiy061. doi:10.1093/femsec/fiy061.

Santoso, B., Kilmaskossu, A. and Sambodo, P. 2007. Effects of saponin from Biophytum petersianum Klotzsch on ruminal fermentation, microbial protein synthesis and nitrogen utilization in goats. Animal Feed Science and Technology 137(1-2), 58-68. doi: 10.1016/j.anifeedsci.2006.10.005.

Santosa, M. B., Robinson, P. H., Williams, P. and Losa, R. 2010. Effects of addition of an essential oil complex to the diet of lactating dairy cows on whole tract digestion of nutrients and productive performance. Animal Feed Science and Technology 157(1- 2), 64-71. doi:10.1016/j.anifeedsci.2010.02.001.

Scharen, M., Drong, C., Kiri, K., Riede, S„ Gardener, M., Meyer, U„ Hummel, J„ Urich, T., Breves, G. and Danicke, S. 2017. Differential effects of monensin and a blend of essential oils on rumen microbiota composition of transition dairy cows. Journal of Dairy Science 100(4), 2765-83. doi:10.3168/jds.2016-11994.

Schofield, P, Mbugua, D. M. and Pell, A. N. 2001. Analysis of condensed tannins: a review. Animal Feed Science and Technology 91(1-2), 21-40. doi: 10.1016/ S0377-8401 (01 >00228-0.

Serrano, J., Puupponen-Pimia, R., Dauer, A., Aura, A. M. and Saura-Calixto, F. 2009. Tannins: current knowledge of food sources, intake, bioavailability and biological effects. Molecular Nutrition and Food Research 53(Suppl. 2), S310-29. doi: 10.1002/ mnfr.200900039.

Sharifi, A. and Chaji, M. 2019. Effects of processed recycled poultry bedding with tannins extracted from pomegranate peel on the nutrient digestibility and growth performance of lambs. South African Journal of Animal Science 49(2), 290-300. doi:10.4314/sajas.v49i2.9.

Sikkema, J., de Bont, J. A. and Poolman, B. 1994. Interactions of cyclic hydrocarbons with biological membranes. Journal of Biological Chemistry 269(11), 8022-8.

Sikkema, J., de Bont, J. A. and Poolman, B. 1995. Mechanisms of membrane toxicity of hydrocarbons. Microbiological Reviews 59(2), 201-22. doi: 10.1128/ MMBR.59.2.201 -222.1995.

Silva,G. G., Takiya, C. S„ Del Valle, T. A., de Jesus, E. F., Grigoletto, N. T. S„ Nakadonari, B„ Cortinhas, C. S., Acedo, T. S. and Renno, F. P. 2018. Nutrient digestibility, ruminal fermentation, and milk yield in dairy cows fed a blend of essential oils and amylase. Journal of Dairy Science 101(11), 9815-26. doi:10.3168/jds.2018-14789.

Silva, R. B. D., Pereira, M. N., Araujo, R. C. D„ Silva, W. D. R. and Pereira, R. A. N. (2020). A blend of essential oils improved feed efficiency and affected ruminal and systemic variables of dairy cows. Translational Animal Science, 4(1), 183..

Sliwinski, B. J., Kreuzer, M., Wettstein, H. R. and Machmuller, A. 2002. Rumen fermentation and nitrogen balance of lambs fed diets containing plant extracts rich in tannins and saponins, and associated emissions of nitrogen and methane. Archives of Animal Nutrition 56(6), 379-92. doi:10.1080/00039420215633.

Smith, A. H. and Mackie, R. I. 2004. Effect of condensed tannins on bacterial diversity and metabolic activity in the rat gastrointestinal tract. Applied and Environmental Microbiology 70(2), 1104-15. doi:10.1128/aem.70.2.1104-1115.2004.

Smith, A. H., Zoetendal, E. and Mackie, R. I. 2005. Bacterial mechanisms to overcome inhibitory effects of dietary tannins. Microbial Ecology 50(2), 197-205. doi: 10.1007/ s00248-004-0180-x.

Soltan,Y. A., Natel, A. S., Araujo, R. C„ Morsy, A. S. and Abdalla, A. L. 2018. Progressive adaptation of sheep to a microencapsulated blend of essential oils: ruminal fermentation, methane emission, nutrient digestibility, and microbial protein synthesis. Animal Feed Science and Technology 237,8-18. doi: 10.1016/j.anifeedsci.2018.01.004.

Soto, E. C„ Molina-Alcaide, E., Khelil, H. and Yanez-Ruiz, D. R. 2013. Ruminal microbiota developing in different in vitro simulation systems inoculated with goats' rumen liquor. Animal Feed Science and Technology 185(1-2), 9-18. doi: 10.1016/j. anifeedsci.2013.06.003.

Souza, K. Ad, Monteschio, JdO., Mottin, C, Ramos, T. R., Pinto, L. AdM., Eiras, С. E., Guerrero, A. and Prado, I. Nd. 2019. Effects of diet supplementation with clove and rosemary essential oils and protected oils (eugenol, thymol and vanillin) on animal performance, carcass characteristics, digestibility, and ingestive behavior activities for Nellore heifers finished in feedlot. Livestock Science 220, 190-5. doi: 10.1016/j. livsci.2018.12.026.

Spanghero, M., Robinson, P. H., Zanfi, C. and Fabbro, E. 2009. Effect of increasing doses of a microencapsulated blend of essential oils on performance of lactating primiparous dairy cows. Animal Feed Science and Technology 153(1-2), 153-7. doi: 10.1016/j. anifeedsci.2009.06.004.

Szumacher-Strabel, M. and Cieslak, A. 2012. Dietary possibilities to mitigate rumen methane and ammonia production. In: Liu, G. (Ed.), Greenhouse Gases-Capturing, Utilization and Reduction. IntechOpen. University of North Dakota, United States of America, pp. 199-218.

Tager, L. R. and Krause, К. M. 2011. Effects of essential oils on rumen fermentation, milk production, and feeding behavior in lactating dairy cows. Journal of Dairy Science 94(5), 2455-64. doi: 10.3168/jds.2010-3505.

Teferedegne, B. 2000. New perspectives on the use of tropical plants to improve ruminant nutrition. Proceedings of the Nutrition Society 59(2), 209-14. doi: 10.1017/ S0029665100000239.

Tekippe, J. A., Hristov, A. N., Heyler, K. S., Cassidy, T. W., Zheljazkov, V. D., Ferreira, J. F. S., Karnati, S. K. and Varga, G. A. 2011. Rumen fermentation and production effects of Origanum vulgare L. leaves in lactating dairy cows. Journal of Dairy Science 94(10), 5065-79. doi:10.3168/jds.2010-4095.

Tekippe, J. A., Tacoma, R., Hristov, A. N.. Lee, C., Oh, J., Heyler, K. S., Cassidy, T. W„ Varga, G. A. and Bravo, D. 2013. Effect of essential oils on ruminal fermentation and lactation performance of dairy cows. Journal of Dairy Science 96(12), 7892-903. doi: 10.3168/ jds.2013-7128.

Terrill, T. H., Douglas, G. B., Foote, A. G„ Purchas, R. W., Wilson, G. F. and Barry, T. N. 1992. Effect of condensed tannins upon body growth, wool growth and rumen metabolism in sheep grazing Sulla (ffedysarum coronarium) and perennial pasture. Journal of Agricultural Science 119(2), 265-73. doi: 10.1017/S0021859600014192.

Theodoridou, K„ Aufrere, J., Andueza, D., Pourrat, J., Le Morvan, A., Stringano, E., Mueller- Harvey, I. and Baumont, R. 2010. Effects of condensed tannins in fresh sainfoin (Onobrychis viciifolia) on in vivo and in situ digestion in sheep. Animal Feed Science and Technology 160(1-2), 23-38. doi: 10.1016/j.anifeedsci.2010.06.007.

Tiemann, T. T, Lascano, С. E., Wettstein, H. R., Mayer, A. C., Kreuzer, M. and Hess, H. D. 2008. Effect of the tropical tannin-rich shrub legumes Calliandra calothyrsus and Flemingia macrophylla on methane emission and nitrogen and energy balance in growing lambs. Animal: an International Journal of Animal Bioscience 2(5), 790-9. doi:10.1017/S1751731108001791.

Tomkins, N. W., Denman, S. E., Pilajun, R„ Wanapat, M„ McSweeney, C. S. and Elliott, R. 2015. Manipulating rumen fermentation and methanogenesis using an essential oil and monensin in beef cattle fed a tropical grass hay. Animal Feed Science and Technology 200, 25-34. doi:10.1016/j.anifeedsci.2014.11.013.

Ultee, A., Bennik, M. H. and Moezelaar, R. 2002. The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus. Applied and Environmental Microbiology 68(4), 1561-8. doi: 10.1128/ aem.68.4.1561-1568.2002.

Utsumi, S. A., Cibils, A. F., Estell, R. E., Soto-Navarro, S. A., Chen, L. and Hallford, D. M. 2013. Effects of adding protein, condensed tannins, and polyethylene glycol to diets of sheep and goats fed one-seed juniper and low quality roughage. Small Ruminant Research 112(1-3), 56-68. doi:10.1016/j.smallrumres.2012.09.006.

Valdez, F. R., Bush, L. J., Goetsch, A. L. and Owens, F. N. 1986. Effect of steroidal sapogenins on ruminal fermentation and on production of lactating dairy cows. Journal of Dairy Science 69(6), 1568-75. doi: 10.3168/jds.S0022-0302(86)80573-2.

Valenzuela-Grijalva, N. V, Pinelli-Saavedra, A., Muhlia-Almazan, A., Dominguez-Di'az, D. and Gonzalez-Rios, H. 2017. Dietary inclusion effects of phytochemicals as growth promoters in animal production. Journal of Animal Science and Technology 59, 8. doi:10.1186/s40781-017-0133-9.

Van Soest, J. P. 1994. Nutritional Ecology of the Ruminant.C omstock Publishing Associates, Cornell University Press, Ithaca, NY and London, UK.

Vasta, V., Yanez-Ruiz, D. R., Mele, M., Serra, A., Luciano, G., Lanza, M., Biondi, L. and Priolo, A. 2010. Bacterial and protozoal communities and fatty acid profile in the rumen of sheep fed a diet containing added tannins. Applied and Environmental Microbiology 76(8), 2549-55. doi:10.1128/AEM.02583-09.

Vasta, V, Daghio, M., Cappucci, A., Buccioni, A., Serra, A., Viti, C. and Mele, M. 2019. Invited review: plant polyphenols and rumen microbiota responsible for fatty acid biohydrogenation, fiber digestion, and methane emission: experimental evidence and methodological approaches. Journal of Dairy Science 102(5), 3781-804. doi:10.3168/jds.2018-14985.

Vokou, D., Kokkini, S. and Bessiere, J.-M. 1993. Geographic variation of Greek oregano (Origanum vulgare ssp. hirtum) essential oils. Biochemical Systematics and Ecology 21 (2), 287-95. doi: 10.1016/0305-1978(93)90047-U.

Wall, E. H., Doane, P. H., Donkin, S. S. and Bravo, D. 2014. The effects of supplementation with a blend of cinnamaldehyde and eugenol on feed intake and milk production of dairy cows. Journal of Dairy Science 97(9), 5709-17. doi: 10.3168/jds.2014-7896.

Wallace, R. J. 2004. Antimicrobial properties of plant secondary metabolites. Proceedings of the Nutrition Society 63(4), 621-9. doi:10.1079/pns2004393.

Wallace, R. J., Arthaud, L. and Newbold, C. J. 1994. Influence of Yucca shidigera extract on ruminal ammonia concentrations and ruminal microorganisms. Applied and Environmental Microbiology 60(6), 1762-7. doi: 10.1128/

AEM.60.6.1762-1767.1994.

Wallace, R. J., McEwan, N. R., McIntosh, F. M., Teferedegne, B. and Newbold, C. J. 2002. Natural products as manipulators of rumen fermentation. Asian-Australasian Journal of Animal Sciences 15(10), 1458-68. doi:10.5713/ajas.2002.1458.

Wang, C. J., Wang, S. P. and Zhou, H. 2009. Influences of flavomycin, ropadiar, and saponin on nutrient digestibility, rumen fermentation, and methane emission from sheep. Animal Feed Science and Technology 148(2-4), 157-66. doi: 10.1016/j. anifeedsci.2008.03.008.

Wang, J. K.,Ye, J. A. and Liu, J.X. 2012. Effects of tea saponinson rumen microbiota, rumen fermentation, methane production and growth performance-a review. Tropical Animal Health and Production 44(4), 697-706. doi: 10.1007/s11250-011-9960-8.

Wang, В., Ma, M. P., Diao, Q. Y. and Tu, Y. 2019. Saponin-induced shifts in the rumen microbiome and metabolome of Young cattle. Frontiers in Microbiology 10, 356. doi: 10.3389/fmicb.2019.00356.

Weimer, P. J. 2015. Redundancy, resilience, and host specificity of the ruminal microbiota: implications for engineering improved ruminal fermentations. Frontiers in Microbiology 6, 296. doi:10.3389/fmicb.2015.00296.

Wina, E., Muetzel, S. and Becker, K. 2005. The impact of saponins or saponin-containing plant materials on ruminant production - a review. Journal of Agricultural and Food Chemistry 53(21), 8093-105. doi:10.1021/jf048053d.

Wina, E., Muetzel, S. and Becker, K. 2006. Effects of daily and interval feeding of Sapindus rarak saponins on protozoa, rumen fermentation parameters and digestibility in sheep. Asian-Australasian Journal of Animal Sciences 19(11), 1580-7. doi: 10.5713/ ajas.2006.1580.

Wink, M. and Schimmer, O. 2018. Modes of action of defensive secondary metabolites. In: Wink, M. and Schimmer, O. (Eds), Annual Plant Reviews Book Series, Volume 3: Functions of Plant Secondary Metabolities and their Exploitation in Biotechnology. John Wiley and Sons, Hoboken, NJ, pp. 18-137.

Yanez-Ruiz, D. R., Bannink, A., Dijkstra, J., Kebreab, E., Morgavi, D. P, O'Kiely, P., Reynolds, С. K„ Schwarm, A., Shingfield, K. J., Yu, Z. and Hristov, A. N. 2016. Design, implementation and interpretation of in vitro batch culture experiments to assess enteric methane mitigation in ruminants-a review. Animal Feed Science and Technology 216,1-18. doi: 10.1016/j.anifeedsci.2016.03.016.

Yang, W. Z., Benchaar, C., Ametaj, B. N., Chaves, A. V., He, M. L. and McAllister, T. A. 2007. Effects of garlic and juniper berry essential oils on ruminal fermentation and on the site and extent of digestion in lactating Cowsl. Journal of Dairy Science 90(12), 5671-81. doi:10.3168/jds.2007-0369.

Yanga, W. Z„ Benchaar, C., Ametaj, B. N. and Beauchemin, K. A. 2010. Dose response to eugenol supplementation in growing beef cattle: ruminal fermentation and intestinal digestion. Animal Feed Science and Technology 158(1-2), 57-64. doi: 10.1016/j. anifeedsci.2010.03.019.

Yoshiki, Y., Kudou, S. and Okubo, K. 1998 Relationship between chemical structures and biological activities of triterpenoid saponins from soybean. Bioscience, Biotechnology, and Biochemistry 62(12), 2291-9. doi:10.1271/bbb.62.2291.

Yuan, Z., Zhang, C, Zhou, L., Zou, C., Guo, Y., Li, W., Liu, J. and Wu, Y. 2007. Inhibition of methanogenesis by tea saponin and tea saponin plus disodium fumarate in sheep. Journal of Animal and Feed Sciences 16(Suppl. 2), 560-5. doi:10.22358/ jafs/74607/2007.

Zebeli, Q. and Ametaj, B. N. 2009. Relationships between rumen lipopolysaccharide and mediators of inflammatory response with milk fat production and efficiency in dairy cows .Journal of Dairy Science 92(8), 3800-9. doi:10.3168/jds.2009-2178.

Zebeli, Q., Mansmann, D., Steingass, H. and Ametaj, B. N. 2010. Balancing diets for physically effective fibre and ruminally degradable starch: a key to lower the risk of sub-acute rumen acidosis and improve productivity of dairy cattle. Livestock Science 127(1), 1 -10. doi: 10.1016/j.Iivsci.2009.09.003.

Zhou, Y. Y., Mao, H. L., Jiang, F., Wang, J. K„ Liu, J. X. and McSweeney, C. S. 2011. Inhibition of rumen methanogenesis by tea saponins with reference to fermentation pattern and microbial communities in Hu sheep. Animal Feed Science and Technology 166- 167, 93-100. doi:10.1016/j.anifeedsci.2011.04.007.

Zhou, C. S„ Xiao, W. J., Tan, Z. L., Salem, A. Z. M., Geng, M. M., Tang, S. X., Wang, M„ Han, X. F. and Kang, J. H. 2012. Effects of dietary supplementation of tea saponins (Ilex kudingcha CJ Tseng) on ruminal fermentation, digestibility and plasma antioxidant parameters in goats. Animal Feed Science and Technology 176(1-4), 163-9. doi:10.1016/j.anifeedsci.2012.07.019.

Zucker, W. V. 1983. Tannins: does structure determine function? An ecological perspective. American Naturalist 121(3), 335-65. doi:10.1086/284065.

Chapter 22_

 
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