Degenerative Disorders of the Brain


Brain circuitry in ageing and neurodegenerative diseaseIntroductionCortico-basal ganglia and cortico-cerebellar circuits: structure and functionThe ageing brain: changes in structure, function, and metabolic integrityStructural changes in the aged brainFunctional changes in the aged brainDifferences in chronological versus brain ageCortico-basal ganglia and fronto-cerebellar networks in ageing and neurodegenerationConcluding remarksAbbreviationsFurther readingReferencesAlzheimer’s disease: prodromal stages and dementiaIntroductionDiagnostic considerationsNeuropathology and biomarkersPrevalence and risk factorsClinical vignetteNeuropsychologyTreatment and managementConcluding remarksAbbreviationsFurther readingReferencesParkinson’s diseaseIntroductionPreliminary considerationsClinical vignetteDiagnostic considerationsBiomarkersEpidemiologyGeneticsNeuropsychologyNeuromodulationTreatmentConcluding remarksAbbreviationsFurther readingReferencesHuntington’s diseaseIntroductionPrevalenceClinical vignetteDiagnostic considerationsGenetics and gene testingJuvenile-onset Huntington’s diseaseNeuropathology, neurophysiology and potential biomarkersClinical symptomsEveryday functioning, care and health-related quality of lifeConcluding remarksAbbreviationsFurther readingReferencesExperience-dependent modulation of neurodegenerative disorders: Huntington’s disease as an exemplarIntroductionPreclinical models of Huntington’s diseaseExperience-dependent modulators of Huntington’s diseaseEnviromimetics as a therapeutic lead for Huntington’s diseaseConcluding remarksAbbreviationsNotesFurther readingReferencesFragile X-associated tremor ataxia syndromeIntroductionPreliminary considerationsClinical vignetteOnset and prevalenceClinical signs and symptomsDiagnostic instruments and clinical rating scalesNeuropsychologyNeuropathology/neurobiological mechanismsTreatment including psychopharmacologyConcluding remarksAbbreviationsFurther readingReferencesMultiple sclerosisIntroductionPreliminary considerationsEpidemiologyEtiologyNeuropathologyClinical presentationDiagnosisClinical courseClinical vignetteMeasures of disease status and progressionTreatmentConcluding remarksAbbreviationsFurther readingReferencesDementia with Lewy bodiesIntroductionA brief epidemiology of dementia with Lewy bodiesNeuropathologyClinical syndromeWakefulness in dementia with Lewy bodiesConcluding remarksAbbreviationsFurther readingReferencesMotor neuron diseaseIntroductionClinical vignetteEpidemiologyClinical presentationPrognosisGenetic factorsDiagnosisNovel diagnostic techniquesCognitive and behavioural manifestationsThe ALS–FTD continuumManagement and potential therapeutic strategiesAbbreviationsFurther readingReferencesNew clinical neuroscience technologies for treating neurodegenerative disordersIntroductionTranscranial magnetic stimulation in clinical neuroscienceTranscranial electrical stimulation: old application, new usesConcluding remarksAbbreviations and glossaryReferences
 
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