Noncoding RNAs in Cholesterol Metabolism and Atherosclerosis
Proper maintenance of cellular and plasma cholesterol levels is critical for proper metabolic function and as such is regulated through tightly controlled mechanisms at both the transcriptional and posttranscriptional level. Cardiometabolic diseases, including atherosclerosis, a prominent cause of human morbidity and mortality in western societies (Glass and Witztum 2001; Lusis 2000), are caused in large part by dysregulation of cholesterol and lipid homeostasis. Although
N.L. Price, PhD (*) • C. Fernandez-Hernando, PhD
© Springer International Publishing AG 2017
T. Thum, S. Dimmeler (eds.), Non-coding RNAs in the Vasculature, Cardiac and Vascular Biology, DOI 10.1007/978-3-319-52945-5_2
many environmental and genetic factors are known to contribute to atherogene- sis, elevated levels of low-density lipoprotein cholesterol (LDL-C) are the primary risk factors for atherosclerosis and are sufficient to drive the progression of this disease. For this reason, the pathways governing plasma LDL-C levels have been extensively studied, and their modulation has led to effective therapies for the treatment of atherosclerosis.