miRNAs and LDL-C Metabolism
While the role of miRNAs in regulating HDL-C metabolism has been extensively studied, the importance of miRNAs in controlling LDL-C remains to be fully elucidated. Nevertheless, a number of studies have reported the importance of miRNAs in controlling circulating LDL-C by regulating cholesterol biosynthesis, very-low- density lipoprotein (VLDL) secretion, and LDLR activity (Fig. 2.2).
- 2 Noncoding RNAs in Cholesterol Metabolism and Atherosclerosis
Fig. 2.2 miRNA regulation of LDL-C metabolism. Schematic overview of miRNAs involved in the regulation of LDL-C metabolism. Blue boxes highlight miRNAs, which regulate genes that control LDL-C. LDLR indicates low-density lipoprotein receptor, MTTP microsomal triglyceride transfer protein, LPL lipoprotein lipase, and NSF N-ethylmaleimide-sensitive factor (Figure was created using the Servier Medical Art illustration resources (http://www.servier.com))