LncRNAs and Cholesterol Metabolism
While the contribution of miRNAs in regulating lipoprotein metabolism has been deeply studied in the last few years, the role of lncRNAs in controlling cholesterol homeostasis has just started to emerge. Recent studies have demonstrated the important contribution of lncRNAs as key regulators of cholesterol metabolism (Fig. 2.3).
- 2 Noncoding RNAs in Cholesterol Metabolism and Atherosclerosis
Fig. 2.3 LncRNA regulation of cholesterol metabolism. Schematic overview of lncRNAs involved in the regulation of hepatic cholesterol homeostasis and lipoprotein metabolism. Blue boxes highlight lncRNAs, which regulate genes that control cholesterol metabolism. FXR indicates farnesoid X receptor, LeXis liver-expressed LXR-induced sequence, LncLSTR liver-specific triglyceride regulator, ApoAl-AS ApoA1 antisense, LPL lipoprotein lipase, and TDP-43 TAR DNA-binding protein 43 (Figure was created using the Servier Medical Art illustration resources (http://www. servier.com))