Overview of Scaffold Reinforcement for Tissue Repair

Xuenan Gu, Fan Wang, and Xiaoming Li

Abstract Nowadays, tissue loss or defect is a major health problem that directly affects the life quality and length of human being. The traditional way to solve the problem is using tissue grafts. However, the source of autografts is limited and this method ineluctably brings additional pains to the patients. Allografts usually causes immunologic rejection and the spread of diseases. Fortunately, tissue engineering scaffolds can overcome these shortages and present a promising method for tissue repair. To achieve desired repair efficacy, the scaffolds need possess appropriate physicochemical performances, among which satisfactory mechanical properties are fundamental. Therefore, to reinforce tissue engineering scaffolds has always been a hot research point. In particular, there are accumulated great achievements in the studies of reinforcing the scaffolds by fibers or tubes during last 20 years. This book will show you the basic knowledge and research progress of the scaffolds reinforced by fibers or tubes, which consists of 8 chapters, concerning comprehensive related issues, such as the mechanism of the tissue engineering scaffolds reinforced by fibers or tubes, the selection or fabrication of novel fibers or tubes to reinforce scaffolds, processing techniques to improve adhesive strength between the matrix and the fibers or tubes, how to get the homogeneous structure and composition throughout the reinforced scaffolds, effects of fibers or tubes on the biocompatibility of the scaffolds, effects of fibers or tubes on the biodegradability of the scaffolds, interactions between fiber or tube reinforced scaffolds and cell/tissue, instrumentation and technology to analyze the interactions between fibers or tubes and matrix, special design and fabrication of novel scaffolds reinforced by fibers or tubes for hard tissue repair, special design and fabrication of novel scaffolds reinforced by fibers or tubes for soft tissue repair, etc. This book will provide special knowledge of materials for the persons with biomedical background, and special biomedical knowledge for the persons with the background of materials, which will hopefully become a valuable informative read for the researchers and students of biomedical engineering major.

Keywords Scaffolds • Tissue repair • Reinforce • Fibers • Tubes

X. Gu • F. Wang • X. Li (*)

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China e-mail: This email address is being protected from spam bots, you need Javascript enabled to view it

© Springer Nature Singapore Pte Ltd. 2017

X. Li (ed.), Tissue Repair, DOI 10.1007/978-981-10-3554-8_1

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