Microsyringe Deposition

Microsyringe deposition is also similar to a layer-by-layer deposition technique in practice, that a polymer is patterned onto a precision-controlled surface using a continuous stream of material via layer-by-layer deposition to fabricate 3D structures with various shapes for tissue engineering [262]. The deposition based on pressure-assisted microsyringe takes use of the compressed air to eject a solution of a polymer in volatile solvent through a narrow capillary needle with ranging a diameter from 10 to 20 pm [47, 263]. Microsyringe deposition takes advantage of the micropositioning system with the lateral precisions of 0.1 pm to manipulate the position of the solution in the x-y plane. The resulting 3D structure has a physical dimensions between 5 and 600 pm, depending upon various processing parameters [120]. The 3D PLGA scaffolds have been fabricated by this technique, so that any synthetic or natural polymer, that is soluble in a volatile solvent, can be used as a material for this method in theory [264].

Microsyringe deposition technique as a young advanced technique offers a convenient method to fabricate multiple 3D scaffolds with micron-scale precision. Low temperature is also conducive to maintaining protein and other biomolecule activity, which is required by creating a favorable microenvironment for tissue repair. Therefore, this technique will be a potential method for creating the reinforced scaffolds in tissue engineering.

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