The Mechanical Properties of the Scaffolds Reinforced by Fibres or Tubes for Tissue Repair

Sreekanth Pentlavalli, Helen O. McCarthy, and Nicholas J. Dunne

Abstract Tissue engineering is a broad technology for tissue repair of diseased or injured tissues and organs by using composite scaffolds. The scaffold material provides stability and creates natural environment to promote cell-seeded population to develop fully functional new tissue or organ by restoring original tissue qualities. Generally, these scaffolds are biocompatible, three dimensional and biodegradable frameworks that act as template for ex-vivo cell expansion. Fibres or tubes reinforced scaffolds are gaining importance due to high mechanical stability and ecoeconomic reasons. This tailored made technology is a combination of both natural and synthetic material which helps to design the scaffold based on needs. To achieve this, fibres or tubes have been used to provide suitable mechanical properties during entire duration of tissue repair. Ideally, fibres reinforced scaffolds must meet following criteria: (i) 3D network with interconnected pore network for cell attachment and growth; (ii) biocompatible and controlled degradation and resorption rate to match tissue growth; (iii) appropriate mechanical properties to match the native tissue at the site of implantation. In this article, we mainly discuss the impact of mechanical properties on various scaffolds such as hydrogel based, ceramic based composites with both natural and synthetic fibres. Also discussed are the various useful techniques used to measure mechanical properties of reinforced materials.

Keywords Mechanical properties • Tissue engineering • Scaffolds • Fibres

S. Pentlavalli • H.O. McCarthy

School of Pharmacy, Queen’s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK N.J. Dunne (*)

School of Pharmacy, Queen’s University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK

Centre for Medical Engineering Research, School of Mechanical and Manufacturing Engineering, Dublin City University, 9 Stokes Building, Collins Avenue, Dublin, Ireland

Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland e-mail: This email address is being protected from spam bots, you need Javascript enabled to view it

© Springer Nature Singapore Pte Ltd. 2017

X. Li (ed.), Tissue Repair, DOI 10.1007/978-981-10-3554-8_3

 
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