Brief Comments

All together, the mechanical properties of scaffolds play crucial roles in scaffolds biocompatibility. The selection of scaffold mechanical properties should take consideration of both the local mechanical properties which is directly sensed by cells and the bulk mechanical properties which is responsible for the transmission of the surrounding mechanical loadings to cells. For scaffolds with identical chemical compositions, the architecture of scaffolds affects both the mechanical properties of scaffolds and the cell/tissue responses. Therefore, the exemplified cell/tissue responses in Sect. 5.4.2 should not be considered as the sole contributions from the mechanical properties of the fibers/tubes-reinforced scaffolds. The core objective of Sect. 5.4 is to provoke concerns for the regulation roles of mechanical properties in 3D scaffold systems to cell/tissue responses and for purposefully tailoring the mechanical properties of scaffolds to induce sound biocompatibility for specific applications.

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