Function of Nerves

Nerve has the function of sensory stimulation and conduction excitatory. Information flow commences at the somatodendritic domain, which receives synaptic input from neighboring or distant neurons. It is subsequently transmitted to the axonal domain, which specializes in sending signals to the next neuron in the neural circuitry or to a target tissue [148].

Cytoskeleton of Nerves

The axon initial segment resides in between axonal and somatodendritic domains serves as the site of action potential firing and helps to maintain neuron polarity. The cytoskeleton is fundamental to the functions of axon initial segment [148]. Neurons use their microtubule arrays as architectural elements required for the elaboration of elongated axons and dendrites [149]. Microtubules and their associated proteins play important roles during the development of neuronal morphology, the plasticity of neurons, and neurodegenerative processes [150]. Microtubules also act as directional railways for organelle transport [149].

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