# Volume-to-Volume Registration

Correspondence between the boundaries can be achieved by nonrigidly registering the images. In this strategy, a volumetric atlas or an average of the training images is first computed. Here, the average is defined as an image that has the smallest bias toward any specific training image. The computed average is then utilized to generate the correspondence. Frangi et al. describe a method to warp the atlas to binary training volumes using multi-resolution B-spline deformation [18]. Rueckert et al. describe a method that constructs a statistical model of the deformation fields [19].

# Volume-to-Volume Registration

Correspondence between the boundaries can be achieved by nonrigidly registering the images. In this strategy, a volumetric atlas or an average of the training images is first computed. Here, the average is defined as an image that has the smallest bias toward any specific training image. The computed average is then utilized to generate the correspondence. Frangi et al. describe a method to warp the atlas to binary training volumes using multi-resolution B-spline deformation [18]. Rueckert et al. describe a method that constructs a statistical model of the deformation fields [19].