Classification of IDPs Based on Their Mechanism, of Action

In another system taking the molecular mechanisms of IDPs into consideration, disordered proteins have been classified into five (Tompa 2002) and later into six categories (Tompa 2005). Further observations suggested the addition of prion proteins as an additional category (Pierce et al. 2005). This classification scheme (Table 6.2) can accommodate all distinct modes of IDP/IDR actions described thus far.

Table 6.2 Classification scheme of IDPs

Protein

Partner

Function

Entropic chains

Nup2p FG repeat region

n.a.

Gating in NPC

K channel N-terminal region

n.a.

Timing of gate inactivation

Display sites

CREB KID

PKA

Phosphorylation site

Cyclin B N-terminal domain

E3 ubiquitin ligase

Ubiquitination site

Chaperones

ERD 10/14

(e.g.) Luciferase

Prevention of aggregation

hnRNP A1

(e.g.) DNA

Strand re-annealing

Effectors

p27Kip1

CycA-Cdk2

Inhibition of cell-cycle

Securin

Separase

Inhibition of anaphase

Assemblers

RNAP II CTD

mRNA maturation factors

Regulation of mRNA maturation

CREB

p300/CBP

Initiation of transcription

Scavengers

Casein

Calcium phosphate

Stabilization of calcium phosphate in milk

Salivary PRPs

Tannin

Neutralization of plant tannins

Prions

Ure2p

Utilization of urea under nitrogen

Sup35p

NusA, mRNA

Suppression of stop codon, translation readthrough

Classification of IDPs encompassing seven functional categories based on their molecular modes of action. Two examples within each category are given, specifying the binding partner (if applicable) and the actual cellular function of the protein

 
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