Both GNPs and MINPs are potential nanobiomaterials that can be promisingly used in biomedical applications for in vivo monitoring and tracking. Both nanobiomaterials can be prepared in different sizes, shapes, concentrations, and surface functionalization to be fit for the specific application. These properties can have an impact on biodistribution and elimination of GNPs and MINPs in vivo. According to the information provided in this review, it seems that the biodistribution and elimination of GNPs and MINPs depends on their properties. The difference in the type of metals seems not to have much impact on biodistribution and elimination. However, the amount of nanotoxicology research has increased and has become attractive to people in the field. Therefore the toxic effects of applying both types of nanobiomaterials for in vivo monitoring and tracking need to be considered.


The author acknowledges the support of the Talent Management Project and the Faculty of Science, Mahidol University, Thailand. The author also thanks Ms. Sunisa Chaicherd and the Center of Nanoimaging, Mahidol University for the technical support of TEM images.

Nanobiomaterials can be defined as the use of materials in a level of nanoscale for biomedical applications. In this chapter an overview of gold and magnetic iron oxide nanoparticles that have been recently applied in biological systems in vivo for diagnostic imaging and treatment of diseases is provided.

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