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Nanoparticulate Systems for Therapeutic and Diagnostic Applications

Rajashekar Kammari, Nandita G. Das, Sudip K. Das

Butler University, Indianapolis, IN, United States

Contents

  • 1. Introduction 105
  • 2. Why Nanotechnology and Nanomedicine? 106
  • 3. Types of Nanoparticles in Drug Delivery 108
  • 3.1 Nonrigid Nanoparticles 108
  • 3.1.1 Liposomes 108
  • 3.1.2 Solid Lipid Nanoparticles 114
  • 3.2 Rigid Nanoparticles 119
  • 3.2.1 Biodegradable Polymeric Nanoparticles 120
  • 3.2.2 Carbon Nanotubes and Nanohorns 126
  • 3.2.3 Iron Nanoparticles 127
  • 4. Conclusion 138

References 138

INTRODUCTION

The multidisciplinary science of nanotechnology is an emerging field where groupings of atoms and molecules are manipulated at the nanometer levels. The concept of nanotechnology was suggested by Richard Feynman in 1959. The term nanotechnology was first introduced by Taniguchi in 1974 and the strategies of nanotechnology were later described by E. Drexler in 1986. The invention of computer imaging systems and high-power microscopes in the late 1980s revolutionized nanotechnology. Nanotechnology has extensive potential in the fields ofpharmacy, physics, biology, and materials science which could combine to contribute toward healthcare. Although the concept of nanotechnology has been explored in healthcare research for the past three decades, it is still considered to be in the early developmental stages as expected therapeutic benefits have not been fully realized [1,2]. Both the academic and industrial communities are investing time and money into the development of nanotherapeutics in order to overcome the perceived challenges and translate the theoretically proven benefits of nanoparticulate systems into clinical advantages. This review mainly focuses on the applications of nanotechnology in drug delivery and diagnosis.

© 2017 Elsevier Inc. All rights reserved.

Emerging Nanotechnologies for Diagnostics, Drug Delivery, and Medical Devices

ISBN 978-0-323-42978-8, http://dx.doi.org/10.1016/B978-0-323-42978-8.00006-1

 
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