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Rigid Nanoparticles

Rigid nanoparticles are known to possess significant mechanical strength compared with the lipid-based nonrigid nanoparticles described thus far. Rigid nanoparticles can be divided into three major subcategories including biodegradable polymeric nanoparticles, carbon nanotubes, and iron nanoparticles.

Biodegradable Polymeric Nanoparticles

Polymeric nanoparticles have been used or are under development for various drugs for the treatment of a wide range of diseases such as cancer, diabetes, malaria, and tuberculosis [79—83]. Polymeric nanoparticles generally supersede other nanoparticulate systems with distinct advantages including better targeting abilities, better long-term storage capabilities and high encapsulation efficiency compared with other carriers. These nanoparticles also control drug release properties, improve intracellular penetration, and increase specificity and therapeutic efficacy of encapsulated drugs [84—89]. Fig. 6.12 schematically represents the types of polymeric nanoparticles based on the drug loading.

 
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