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Peptide and Protein-Based Therapeutic Agents

Mary Joseph, Hoang M. Trinh, Ashim K. Mitra

University of Missouri—Kansas City, Kansas City, MO, United States

Contents

  • 1. Introduction 146
  • 2. Challenges With Peptide and Protein Therapeutics 147
  • 3. Chemical Modifications 147
  • 3.1 PEGylation 147
  • 3.2 Glycosylation 148
  • 3.3 Mannosylation 149
  • 4. Micro- and Nanotechnology for Biologics in Drug Delivery 150
  • 4.1 Microparticles or Microspheres 150
  • 4.2 Nanoparticles 151
  • 4.3 Solid Lipid NP 152
  • 4.4 Carbon Nanotube 152
  • 4.5 Liposomes 153
  • 4.6 Aquasomes 154
  • 4.7 Micelles 154
  • 5. Protein-and Peptide-Based Therapeutics 155
  • 5.1 Therapeutic Applications 155
  • 5.1.1 Cancer 155
  • 5.1.2 Ocular Diseases 156
  • 5.1.3 Other Diseases 157
  • 5.2 Diagnostic Applications 157
  • 5.2.1 Magnetic Nanoparticles 157
  • 5.2.2 Carbon Nanotubes and Gold Nanoparticles 159
  • 5.2.3 Other Protein/Peptide Diagnostics 160
  • 6. Conclusion 161

References 161

Chapter Objectives

  • • To outline fundamental concepts of peptide and protein drugs for various therapeutic use.
  • • To provide an insight on challenges of peptide and protein drug delivery.

© 2017 Elsevier Inc. All rights reserved.

  • • To examine effects of glycosylation, PEGylation, and mannosylation in peptide and protein drug delivery.
  • • To delineate various colloidal systems employed in delivery of peptide and proteins.
 
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