Menu
Home
Log in / Register
 
Home arrow Engineering arrow Emerging nanotechnologies for diagnostics, drug delivery and medical devices
Source

CONCLUSION

This review provides a synopsis of the research being carried out in the field of intracellular drug delivery. It also outlines some of the critical parameters that need to be factored in while designing nanostructures with site of action inside the cell. As mentioned previously this exciting field of research is still in early stages. A lot of work needs to be done to answer many important questions.

REFERENCES

[1] Smith PJ, et al. Cellular entry of nanoparticles via serum sensitive clathrin-mediated endocytosis, and plasma membrane permeabilization. Int J Nanomed 2012;7:2045-55.

[2] Ferreira F, et al. Endocytosis of G protein-coupled receptors is regulated by clathrin light chain phosphorylation. Curr Biol 2012;22(15):1361-70.

[3] Ford MG, et al. Curvature of clathrin-coated pits driven by epsin. Nature 2002;419(6905):361-6.

[4] Mayor S, Pagano RE. Pathways of clathrin-independent endocytosis. Nat Rev Mol Cell Biol 2007; 8(8):603-12.

[5] Thomsen P, Roepstorff K, Stahlhut M, van Deurs B. Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking. Mol Biol Cell 2002;13(1): 238-50.

[6] Simons K, Ikonen E. Functional rafts in cell membranes. Nature 1997;387(6633):569-72.

[7] Hao X, et al. Caveolae mediated endocytosis ofbiocompatible gold nanoparticles in living Hela cells. J Phys Condens Matter 2012;24(16):164207.

[8] Wang Z, Tiruppathi C, Minshall RD, Malik AB. Size and dynamics of caveolae studied using nanoparticles in living endothelial cells. ACS Nano 2009;3(12):4110-6.

[9] Doherty GJ, McMahon HT. Mechanisms of endocytosis. Annu Rev Biochem 2009;78:857-902.

[10] Grassart A, Dujeancourt A, Lazarow PB, Dautry-Varsat A, Sauvonnet N. Clathrin-independent endo-

cytosis used by the IL-2 receptor is regulated by Rac1, Pak1 and Pak2. EMBO Rep 2008;9(4): 356-62.

[11] Lundmark R, et al. The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway. Curr Biol 2008;18(22):1802-8.

[12] Ge L, et al. Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake. Proc Natl Acad Sci USA 2011;108(2):551-6.

[13] Strauss K, et al. Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type

C disease. J Biol Chem 2010;285(34):26279-88.

[14] Vercauteren D, et al. Dynamic colocalization microscopy to characterize intracellular trafficking of nanomedicines. ACS Nano 2011;5(10):7874-84.

[15] Kasper J, et al. Flotillin involved uptake of silica nanoparticles and responses of an alveolar-capillary barrier in vitro. Eur J Pharm Biopharm 2013;84(2):275-87.

[16] Liberali P, et al. The closure of Pak1-dependent macropinosomes requires the phosphorylation of CtBP1/BARS. EMBO J 2008;27(7):970-81.

[17] Dharmawardhane S, et al. Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell 2000;11(10):3341-52.

[18] Fujii M, Kawai K, Egami Y, Araki N. Dissecting the roles of Rac1 activation and deactivation in mac- ropinocytosis using microscopic photo-manipulation. Sci Rep 2013;3:2385.

[19] Grimmer S, van Deurs B, Sandvig K. Membrane ruffling and macropinocytosis in A431 cells require cholesterol. J Cell Sci 2002;115(Pt. 14):2953-62.

[20] Mercer J, Helenius A. Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells.

Science 2008;320(5875):531-5.

[21] Hoon JL, et al. Functions and regulation of circular dorsal ruffles. Mol Cell Biol November 2012;

32(21):4246-57.

[22] Harush-Frenkel O, et al. Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells. Biomacromolecules 2008;9:435-43.

[23] Kim S, et al. Phagocytosis and endocytosis of silver nanoparticles induce interleukin-8 production in human macrophages. Yonsei Med J 2012;53(3):654-7.

[24] RinkJ, Ghigo E, Kalaidzidis Y, Zerial M. Rab conversion as a mechanism of progression from early to late endosomes. Cell 2005;122(5):735-49.

[25] Mercer J, Helenius A. Gulping rather than sipping: macropinocytosis as a way of virus entry. Curr Opin Microbiol 2012;15(4):490-9.

[26] Spang A. On the fate of early endosomes. Biol Chem 2009;390(8):753-9.

[27] Mu FT, et al. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine “fingers” and contains a calmodulin-binding IQ motif.

J Biol Chem 1995;270(22):13503-11.

[28] Lakadamyali M, Rust MJ, Zhuang X. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 2006;124(5):997-1009.

[29] Hanson PI, Cashikar A. Multivesicular body morphogenesis. Annu Rev Cell Dev Biol 2012;28: 337-62.

[30] Murk JL, et al. Influence of aldehyde fixation on the morphology of endosomes and lysosomes: quantitative analysis and electron tomography. J Microsc 2003;212(Pt. 1):81-90.

[31] Ostrowski M, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 2010;12(1):19-30. sup pp. 11-13.

[32] Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W, Geuze HJ. Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 2000;113(Pt. 19):3365-74.

[33] Sahay G, et al. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol 2013;31(7):653-8.

[34] Cruz JC, Sugii S, Yu C, Chang TY. Role ofNiemann-Pick type C1 protein in intracellular trafficking of low density lipoprotein-derived cholesterol. J Biol Chem 2000;275(6):4013-21.

[35] Rajendran L, et al. Subcellular targeting strategies for drug design and delivery. Nat Rev Drug Discov 2010;9:29-42.

[36] Sakhrani NM, Harish P. Organelle targeting: third level of drug targeting. Drug Des Devel Ther 2013; 7:585-99.

[37] Qagdas M, Sezer AD, Bucak S. Liposomes as potential drug carrier systems for drug delivery. In: Sezer AD, editor. Application of nanotechnology in drug delivery. InTech; 2014. http:// dx.doi.org/10.5772/58459.

[38] Galvez T, Gilleron J, Zerial M, O’Sullivan GA. SnapShot: mammalian Rab proteins in endocytic trafficking. Cell 2012;151(1):234.

[39] Sandin P, Fitzpatrick LW, Simpson JC, Dawson KA. High-speed imaging of Rab family small GTPases reveals rare events in nanoparticle trafficking in living cells. ACS Nano 2012;6(2):1513-21.

[40] SchroderBA, Wrocklage C, Hasilik A, Saftig P. The proteome oflysosomes. Proteomics 2010;10(22): 4053-76.

[41] Mellman I, Fuchs R, Helenius A. Acidification of the endocytic and exocytic pathways. Annu Rev Biochem 1986;55:663-700.

[42] Noguiera DR, et al. Mechanisms underlying cytotoxicity induced by engineered nanomaterials: a review of in vitro studies. Nanomaterials 2014;4:454-84.

[43] Sahay G, et al. Endocytosis of nanomedicines. J Control Release August 3, 2010;145(3):182-95.

[44] Prokop A, Davidson JM. Nanovehicular intracellular delivery systems. J Pharm Sci September 2008; 97(9):3518-90.

[45] Herd H, et al. Nanoparticle geometry and surface orientation influences mode of cellular uptake. ACS Nano March 26, 2013;7(3). http://dx.doi.org/10.1021/nn304439f.

[46] Ulbrich K, et al. Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies. Chem Rev 2016;116(9).

[47] Walter P, et al. The protein translocation machinery of the endoplasmic reticulum. Philos Trans R Soc Lond B Biol Sci 1982;300(1099):225-8.

[48] Allen TD, et al. The nuclear pore complex: mediator of translocation between nucleus and cytoplasm. J Cell Sci 2000;113(Pt. 10):1651-9.

[49] Stoffler D, Fahrenkrog B, Aebi U. The nuclear pore complex: from molecular architecture to functional dynamics. Curr Opin Cell Biol 1999;11(3):391-401.

[50] Intracellular delivery: Fundamentals and applications. In: Prokop A, editor. Fundamental Biomedical

Technologies; 2011.

[51] Zanta MA, Belguise-Valladier P, Behr JP. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci USA 1999;96(1):91-6.

[52] D’Souza GG, et al. DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells. J Control Release 2003;92(1-2):189-97.

[53] D’Souza GG, Boddapati SV, Weissig V. Mitochondrial leader sequence—plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria. Mitochondrion

2005;5(5):352-8.

[54] D’Souza GG, et al. Nanocarrier-assisted sub-cellular targeting to the site of mitochondria improves the pro-apoptotic activity of paclitaxel. J Drug Target 2008;16(7):578-85.

[55] Yamada Y, et al. MITO-Porter: A liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion. Biochim Biophys Acta 2008;1778(2):423-32.

[56] Murugan K, et al. Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures. IntJ Nanomedicine 2015;2015(10):2191-206.

[57] OhJM, et al. Intracellular drug delivery of layered double hydroxide nanoparticles. J Nanosci Nano- technol 2011;11:1632-5.

[58] Deepthi A, et al. Targeted drug delivery to the nucleus and its potential role in cancer chemotherapy. J Pharm Sci Res 2013;5(2):48-56.

[59] Wente SR, Rout PM. The nuclear pore complex and nuclear transport. Cold Spring Harb Perspect Biol 2010;2(10):a000562.

[60] Sykes EA, et al. Investigating the impact of nanoparticle size on active and passive tumor targeting efficiency. ACS Nano 2014;8(6):5696-706.

[61] Tkachenko, et al. Multifunctional gold nanoparticle-peptide complexes for nuclear targeting. J Am Chem Soc 2003;125(16):4700-1.

[62] Moroianu J, Blobel G, Radu A. The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence. Proc Natl Acad Sci USA 1996;93(13):6572—6.

[63] Erazo-Oliveras A, Muthukrishnan N, Baker R, Wang T-Y, Pellois J-P. Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges. Pharmaceuticals (Basel, Switz) 2012;5(11). http://dx.doi.org/10.3390/ph5111177.

[64] Zhou X, et al. Double-exposure optical sectioning structured illumination microscopy based on Hilbert transform reconstruction. PLoS One 2015;10(3):e0120892.

[65] Smith IO, Ren F, Baumann MJ, Case ED. Confocal laser scanning microscopy as a tool for imaging cancellous bone. J Biomed Mater Res 2006;79B:185—92.

[66] Cartiera MS, Johnson KM, Rajendran V, Caplan MJ, Saltzman WM. The uptake and intracellular fate of PLGA nanoparticles in epithelial cells. Biomaterials 2009;30(14):2790—8.

[67] Kramer IJ, Sargent EH. The architecture of colloidal quantum dot solar cells: materials to devices. Chem Rev 2014;114:863—82.

[68] Walling MA, Novak JA, Shepard JRE. Quantum dots for live cell and in vivo imaging. Int J Mol Sci 2009;10(2):441—91.

[69] Brendenberger C, et al. Intracellular imaging of nanoparticles: is it an elemental mistake to believe what you see? Part Fibre Toxicol 2010;7:15.

[70] Derfus AM, et al. Intracellular delivery of quantum dots for live cell labelling and organelle tracking. Adv Mater June 17, 2004;16(12).

[71] Huang X, El-Sayed M. Gold nanoparticles: optical properties and implementations in cancer diagnosis and photothermal therapy 2010;1(1):13—28.

[72] Sonnichsen C, Franzl T, Wilk T, von Plessen G, Feldmann J, Wilson O, et al. Drastic reduction of plasmon damping in gold nanorods. Phys Rev Lett 2002;88:077402.

[73] Yguerabide J, Yguerabide EE. Light-scattering submicroscopic particles as highly fluorescent analogs and their use as tracer labels in clinical and biological applications I. theory. Anal Biochem 1998;262: 137—56.

[74] Tkachenko AG, Xie H, Coleman D, Glomm W, Ryan J, Anderson MF, et al. Multifunctional gold nanoparticle peptide complexes for nuclear targeting. J Am Chem Soc 2003;125:47001.

[75] Kumar S, Harrison N, Richards-Kortum R, Sokolov K. Plasmonic nanosensors for imaging intracellular biomarkers in live cells. Nano Lett 2007;7:133843.

[76] Thomas M, Klibanov AM. Non-viral gene therapy: polycation-mediated DNA delivery. Appl Microbiol Biotechnol 2003;62:2734.

[77] Chithrani DB, Dunne M, Stewart J, Allen C, Jaffray DA. Cellular uptake and transport of gold nanoparticles incorporated in a liposomal carrier. Nanomedicine 2009;6:1619.

[78] Yang PH, Sun XS, Chiu JF, Sun HZ, He QY. Transferrin-mediated gold nanoparticle cellular uptake. Bioconj Chem 2005;16:4946.

[79] Soman NR, Marsh JN, Lanza GM, Wickline SA. New mechanisms for non-porative ultrasound stimulation of cargo delivery to cell cytosol with targeted perfluorocarbon nanoparticles. Nanotechnology 2008;19:185102.

[80] Feldherr CM, Lanford RE, Akin D. Signal-mediated nuclear transport in Simian-virus 40-transformed cells is regulated by large tumor-antigen. Proc Natl Acad Sci USA 1992;89:110025.

 
Source
Found a mistake? Please highlight the word and press Shift + Enter  
< Prev   CONTENTS   Next >
 
Subjects
Accounting
Business & Finance
Communication
Computer Science
Economics
Education
Engineering
Environment
Geography
Health
History
Language & Literature
Law
Management
Marketing
Mathematics
Political science
Philosophy
Psychology
Religion
Sociology
Travel