Electrospun Nanofibers in Biomedical Application

Electrospun NF scaffolds possess properties of interconnection between pores and cell adhesion, infiltration, migration, and proliferation, while permitting free exchange of cell nutrients and wastes in addition to a high surface-to-volume ratio. Other characteristics of the electrospun NF include surface modification of bioactive molecules, cell recognizable ligands, and the ability of imitating natural ECM in addition to the mechanical strength, biocompatibility, and biodegradability. Electrospun NF shows remarkable application in drug delivery, wound dressing, medical implants, biosensors, and dental surgery (as discussed earlier). Electrospun NF offers a cost-effective method to mimic native ECM composed of an interlocking meshwork of proteins and glycosaminoglycans. Other important raw materials include PCL, PLA, PGA, PLGA, and PLCL. These copolymers are very suitable because of their ease of processing, mechanical properties, and biocompatibility. Natural polymers, such as collagen, gelatin, chitosan, and silk fibroin, have also been electrospun into NF scaffolds for biomedical applications [86].

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