Nanosystems for Diagnostic Imaging, Biodetectors, and Biosensors

Gayathri Acharya1, Ashim K. Mitra2, Kishore Cholkar3

GlaxoSmithKline, Collegeville, PA, United States; 2University of Missouri—Kansas City, Kansas City, MO, United States; 3Ingenus Pharmaceuticals/RiconPharma LLC, Denville, NJ, United States

Contents

  • 1. Introduction 217
  • 2. Nanosystems as Platforms for Advanced Diagnostic Imaging 218
  • 2.1 Iron Oxide Nanoparticles 218
  • 2.2 Quantum Dots 220
  • 2.3 Gold Nanoparticles 221
  • 2.4 Carbon Nanotubes 222
  • 2.5 Silica Nanoparticles 222
  • 2.6 Liposomes 223
  • 2.7 Nanomicelles 224
  • 2.8 Dendrimers 225
  • 3. Diagnostic Imaging With Nanosystems 226
  • 3.1 Magnetic Resonance Imaging 227
  • 3.2 Optical Imaging 228
  • 3.3 Nuclear Imaging 230
  • 3.4 Computed Tomography 230
  • 3.5 Ultrasound 231
  • 4. Biological Sensors 232
  • 4.1 Glucose Sensors 233
  • 4.1.1 Immobilized Enzyme Film Glucose Biosensors 234
  • 4.1.2 Nanoparticle/Carbon Nanotube—Based Glucose Biosensors 235
  • 4.1.3 Mechanism of Nonenzymatic Glucose Biosensors 238
  • 4.2 Microcantilever 239
  • 4.2.1 Mechanism of Microcantilever Deflection 239
  • 5. Conclusions 244

References 244

 
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