Solid Lipid Nanoparticles in Drug Delivery: Opportunities and Challenges

Ameya Deshpande, Majrad Mohamed, Saloni B. Daftardar, Meghavi Patel, Sai H.S. Boddu, Jerry Nesamony

The University of Toledo Health Science Campus, Toledo, OH, United States

Contents

  • 1. Introduction 292
  • 2. Components of Solid Lipid Nanoparticles 293
  • 2.1 Lipid 293
  • 2.2 Surfactant 295
  • 3. Solid Lipid Nanoparticle Production Techniques 295
  • 3.1 High-Pressure Homogenization 295
  • 3.1.1 Hot Homogenization Technique 296
  • 3.1.2 Cold Homogenization Technique 296
  • 3.2 Microemulsion-Based Technique 297
  • 3.3 Solvent Emulsification—Evaporation Technique 297
  • 3.4 Solvent Displacement Technique 298
  • 3.5 Emulsification—Diffusion Technique 298
  • 4. Drug-Loading Capacity of Solid Lipid Nanoparticles 298
  • 5. Drug Incorporation Models of Solid Lipid Nanoparticles 299
  • 6. Drug Release From Solid Lipid Nanoparticles 300
  • 6.1 Influence of Temperature 301
  • 6.2 Influence of Surfactants 302
  • 7. Applications of Solid Lipid Nanoparticles for Drug Delivery 302
  • 7.1 Routes of Administration of SLNs 302
  • 7.1.1 Oral Administration 302
  • 7.1.2 Parenteral Route 303
  • 7.1.3 Topical Administration 304
  • 7.1.4 Pulmonary Administration 305
  • 7.1.5 Rectal Administration 305
  • 7.1.6 Ocular Administration 306
  • 7.2 Application of Solid Lipid Nanoparticles for Delivery of Hydrophilic Drugs: PEG Coating 307
  • 7.3 SLNs as Potential Carriers of Anticancer Agents 308
  • 7.3.1 Significance of Solid Lipid Nanoparticles as Anticancer Carriers 308
  • 7.3.2 Incorporation of Hydrophilic Anticancer Actives in Solid Lipid Nanoparticles 310
  • 8. Stability Concerns of Solid Lipid Nanoparticles 310
  • 8.1 Influence of Shear Forces and Lipid Concentration 311

Emerging Nanotechnologies for Diagnostics, Drug Delivery, and Medical Devices © 2017 Elsevier Inc.

ISBN 978-0-323-42978-8, http://dx.doi.org/10.1016/B978-0-323-42978-8.00012-7 All rights reserved.

  • 8.2 Influence of the Surface of the Packing Material 311
  • 8.3 Properties of the Lipids: SLNs Versus Bulk Material 312
  • 8.4 Stability and Storage Conditions 312
  • 8.5 Gelling Tendency: Temperature Versus Shear Forces 314
  • 8.6 Physical Stability 315
  • 8.6.1 Physical Stability due to Changes in Lipids 315
  • 8.6.2 Physical Stability due to Changes in Colloidal Lipid Dispersion 318
  • 8.6.3 Coalescence 318
  • 8.7 Chemical Stability 318
  • 8.7.1 Phospholipid Stability 318
  • 8.7.2 Triglycerides Stability 319
  • 9. Toxicity Aspects of Solid Lipid Nanoparticles 319
  • 10. Diagnostic Applications of Solid Lipid Nanoparticles 320
  • 11. In Vivo Fate of Solid Lipid Nanoparticles 321
  • 12. Conclusions 322

References 323

 
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