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Home arrow Environment arrow Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management
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Other Laboratory Measures

CSF CSF analysis can be helpful if performed in a specialty laboratory. Increased intrathecal IgG synthesis, measurement of the increase in the proportion of gamma globulin by CSF electrophoresis, and the presence of CSF oligoclonal bands increase the likelihood of a diagnosis of MS [7-9, 11]. Neurofilament chains are potential markers for axonal injury as seen in gadolinium-enhancing lesions in RRMS and progressive forms of MS [63, 64].

Glial Fibrillary Acidic Protein (GFAP) Concentration CSF GFAP is raised in SPMS and associated with expanded disability status scale (EDSS) scores [65].

Evoked Response Testing Visual evoked responses carried out in an established laboratory too can be helpful in making a diagnosis [9]. Other evoked responses, brain stem and somatosensory, can be abnormal in other diseases as well as MS, and the studies are technically more difficult. Spinocerebellar degenerations are often associated with markedly abnormal auditory evoked potentials, for example.

 
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