Cell-Derived Microparticles/Exosomes in Neuroinflammation

Lawrence L. Horstman, Wenche Jy, and Yeon S. Ahn

Abbreviations of Diseases Are as Usual in Neurology

ALS Amyotrophic lateral sclerosis MS Multiple sclerosis PD Parkinson’s disease TBI Traumatic brain injury

Fundamentals and Terminology Introduction

After long controversy, it is now recognized that essentially all neurodegenerative diseases have inflammatory components [1]. Many other neurological disorders are exacerbated by inflammation, including the progressive impairment following stroke or traumatic brain injury (TBI). It has been known that levels of circulating cell-derived microparticles (MP) are generally increased in inflammatory states, making them useful as biomarkers. More recently, certain species of MP or exo- somes have been implicated as causative agents in neuroinflammation, to be reviewed.

L.L. Horstman, BS • W. Jy, PhD (*) • Y.S. Ahn, MD

University of Miami, Department of Medicine (Wallace H. Coulter Platelet Laboratory), 1600 NW 10TH Ave., Mail Code R36A, Miami, FL 33136, USA e-mail: This email address is being protected from spam bots, you need Javascript enabled to view it

© Springer International Publishing AG 2017

A. Minagar, J.S. Alexander (eds.), Inflammatory Disorders of the Nervous System, Current Clinical Neurology, DOI 10.1007/978-3-319-51220-4_6

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