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Home arrow Environment arrow Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management
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Bioactive Lipids

Many bioactive lipids are available on MP, and oxidized phospholipids (oxPL) on them are also pro-inflammatory [75]. However, if inflammatory lipids are critical in neurodegenerative diseases, the question arises, why do they not respond well to NSAIDs? i.e., to cyclooxygenase (COX) inhibitors? To answer that, Fiebich et al. propose a novel “two-hit” cycle involving prostaglandin and ATP released from injured cells [76]. MP-associated bioactive lipids in neuroinflammation were discussed in our earlier review.

Cell-Cell Signals ("Cross Talk")

All of the above agents can be transferred from cell to cell via MP, such as neuron- glia “cross talk” [77]. Evidence shows that lipid raft regions of the cell are crucial in cell-cell signal functions [78-80], consistent with evidence that MP are released from lipid rafts. An emerging paradigm is the central role of lipid rafts in the release of MP/exosomes, in cell-cell signaling, in transmission of viral and other microbial infections, and in prion/prion-like diseases, as cited in following sections.

 
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