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Home arrow Environment arrow Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management
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Recent Advances: MP in Selected Neuroinflammatory States

Some of the disorders in this article are considered from more than one perspective; continue in the next section (protein-misfolding diseases).

MP in Brain Injury and Neurovascular Dysfunction

Some sources on this were earlier cited, regarding infection in section “Micro-RNA (miRNA)” [47] and ischemic brain injury in section “Matrix Metaloproteinases (MMPs)” [61]. Brain injury of several causes such as stroke or trauma present similar neuroinflammatory profiles in the progressive worsening of disability for up to 7 days following the initial insult. This progressive deterioration is attributed to inflammatory responses such as oxidative stress.Traumatic brain injury (TBI), ischemic stroke, and hemorrhagic stroke have similar post-event sequelae in the neurovascular unit [81].

The review of Terasaki et al. [81] prominently cites evidence supporting a causative role for MP in the progressive decline following brain injury. Taylor advocates MP as useful biomarkers for monitoring TBI [82]. Rivero et al. provide an up-to- date account of exosome-mediated inflammatory signaling pathways and demonstrate that administration of exosomes loaded with selected siRNA improves indicators of recovery in an animal model with spine injury [83]. Sanborn et al. have characterized the rise and fall of some MP subtypes post-subarachnoid hemorrhage [84].

 
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