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Home arrow Environment arrow Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management
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Statin Therapy and Hypothesis

Many studies led to a major clinical trial of simvastatin for MS, with finding of significant benefits [136], as discussed [137, 138]. However, the explanation for the benefit was not clear. In view of work cited above, it is possible that the benefit results from reduced release of MP. Release of MP is strongly dependent on ample cellular cholesterol [139], thus one of the pleiotropic effects of statins [140] is reduction of MP release [141, 142]. This may also bear on the anti-inflammatory action of statins. For example, in a rat model of hemorrhagic stroke, simvastatin reduced post-injury mortality [143], attributed to mitigation of inflammation. Release of some virions has similar lipid raft dependence [92]. On the other hand, mounting evidence indicates that statins applied to neuroinflammatory disorders can have adverse effects [140]. The adverse effects may be explained in the same terms, insofar as MP/exosomes constitute a network of signals, many of which are neuroprotective and regenerative [144]. Incidentally, it is interesting that measles virus impairs cholesterol biosynthesis [145], possibly to avoid easy shedding in MP, thus evading innate immunity.

 
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