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Home arrow Environment arrow Inflammatory Disorders of the Nervous System: Pathogenesis, Immunology, and Clinical Management
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Treatment of Inclusion Body Myositis

At the present time, there are no effective drug treatments for IBM. The usual treatments for other inflammatory have all been tried, but none have been of any therapeutic benefit. These treatments have included prednisone, azathioprine, IVIg, methotrexate, lithium, beta-interferon, and many others. There are current trials with the monoclonal antibody bimagrumab (BYM338) that inhibits activin type II receptors that have the effect of inhibiting muscle atrophy. This treatment has been shown to cause an increase in thigh muscle mass measured with MRI in a small group of patients. Follistatin is a myostatin inhibitor that has the potential to increase muscle mass. Other trials with arimoclomol, etanercept, and alemtuzumab have been completed though results of the trials are not published [1, 7, 12]. Further information about drug trials can be obtained through the website, Clinicaltrials.gov.

Current therapy of IBM is supportive. There is evidence that exercise can be facilitated by physical and occupation therapists. The major goal is to maintain strength and prevent falls. The use of assistive devices and orthoses may help in achieving these same goals [5].

 
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