Menu
Home
Log in / Register
 
Home arrow Health arrow Analysis of Protein Post-Translational Modifications by Mass Spectrometry
Source

Protein Acetylation and Methylation

Caroline Evans

Department of Chemical and Biological Engineering, University of Sheffield, Sheffield, UK

Overview of Protein Acetylation and Methylation

Protein acetylation and methylation are post-translational modifications (PTMs) occurring predominantly on arginine (methylation) and lysine (acetylation and methylation) residues. Acetylation can also occur at the N-terminus and acts as multifunctional regulator including regulation of protein stability, via a specific degradation signal, termed the Ac/N-degron [1]. Originally considered epigenetic modifications that occurred mainly or exclusively on histones, it has become clear that acetylation and methylation also occur on a range of nonhistone proteins [2, 3] with modification rates that are subject to metabolic control [4]. As such these PTMs can be considered key regulatory events in cell function. Acetylation and methylation, as for other PTMs, can occur singly or in combination providing mechanisms for regulating protein activity through generating functional variants and regulatory sites. MS analysis of acetylation and methylation is directed not only to site identification and localization but also characterization of their combinations [5, 6].

 
Source
Found a mistake? Please highlight the word and press Shift + Enter  
< Prev   CONTENTS   Next >
 
Subjects
Accounting
Business & Finance
Communication
Computer Science
Economics
Education
Engineering
Environment
Geography
Health
History
Language & Literature
Law
Management
Marketing
Mathematics
Political science
Philosophy
Psychology
Religion
Sociology
Travel