Different serological tests

Serological tests may be divided into conventional and nonconventional methods. The first group comprises the classical methods used for diagnosis since the discovery of the disease. They use antigenic mixtures, most are commercialized and able to diagnose most infected individuals. Great experience in all endemic countries has been achieved with time and many groups of investigation published results comparing their performance. Nonconventional methods were introduced since 1980, but most are not available for universal use (not commercially available) and experiences with their results are restricted to a few groups.

Conventional methods The complement fixation test (CF)

This was the first test employed for diagnosis, very soon after the discovery of the disease.2 Most of reagents were prepared in house and the test was time-consuming when a large amount of samples were necessary to test, as in blood banks. By the time that standardization was ready, other simpler tests were progressively substituting for the CF (mainly HA and IIF). By 1985 most laboratories abandoned the CF, moving to simpler tests. Nowadays, no commercial kits are available anymore.

 
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