HIT (Linking Herbal Active Ingredients to Targets)

HIT13 is a curated database to complement available resources on protein targets for United States Food and Drug Administration-approved drugs and promising precursors. It currently contains ~1301 known protein targets

Table 10.1 Databases for herbal and traditional medicines.

Database

Website

Description0

New release

Chem-TCM: Chemical Database of traditional Chinese Medicine

www.chemtcm.com/

The Chem-TCM database gathers 12 070 chemical records, constituents of ~350 herbs used in traditional Chinese medicine. There are >9500 unique molecular records adjusted for overlapping presence in multiple plants and different stereochemistry

2011

Hit: linking herbal active ingredients to targets

http://lifecenter.sgst.

cn/hit/

HIT is a comprehensive and fully curated database to complement available resources on protein targets for FDa-approved drugs, as well as promising precursors

2011

TCMsp: Traditional Chinese Medicine systems pharmacology Database and analysis platform

http://lsp.nwsuaf.edu.

cn/tcmsp.php

TCMsp is a unique systems pharmacology platform of Chinese herbal medicines that captures the relationships between drugs, targets and diseases

2014

TCMGeneDIT: a database for associated TCM, gene and disease information using text mining

http://tcm.lifescience.

ntu.edu.tw/index.

html

TCMGeneDIT is a database system providing association information about TCMs, genes, diseases, TCM effects, and TCM ingredients automatically mined from vast amount of biomedical literature

2008

TCMID: Traditional Chinese Medicine Integrated Database for herb molecular mechanism analysis

www.megabionet.org/

tcmid/

TCMID is a comprehensive database to provide information and bridge the gap between TCM and modern life sciences

2012

TTD: Therapeutic Targets Database

http://bidd.nus.edu.sg/

group/ttd/ttd.asp

TTD Version 5.1.01 provides 1008, 369, and 119 nature-derived approved, clinical trial, and preclinical drugs, respectively, together with their species origin information. all data are available for users to download

2016

Table 10.2 Chem-TCM built the database according to 26 traditional Chinese medicine categories.

1

Release the exterior (warm, acrid herbs)

2

Release the exterior (cool, acrid herbs)

3

Drain fire

4

Cool the blood

5

Clear heat and relieve toxicity

6

purgatives

7

Cathartics

8

Drain dampness

9

Dispel wind-damp

10

Cool and transform phlegm-heat

11

Warm and transform phlegm-cold

12

treat cough and wheezing

13

Aromatically transform damp

14

regulate the Qi

15

stop bleeding

16

Invigorate the blood

17

Warm the interior and expel cold

18

Tonify the Qi

19

tonify the blood

20

tonify the Yang

21

tonify the Yin

22

stabilize and bind (astringents)

23

Nourish the heart and calm the spirit

24

Aromatically clear the orifices of the heart

25

Extinguish wind and stop tremors

26

Expel parasites

derived from 3258 items of literature, which covers ~586 active compounds from 1305 Chinese herbs. The molecular target information involves those proteins being directly/indirectly activated or inhibited, protein binders, and enzymes whose substrates or products are those compounds. Detailed interaction values such as IC50 and Kd/Ki are also provided. HIT also includes genes that are up- or down-regulated under the treatment of individual ingredients.

The homepage (http://lifecenter.sgst.cn/hit/) of HIT is shown in Figure 10.1A. It may be searched by compound, herb, and protein target in Chinese or English. For example, keying in “^^” or “Radix Glycyrrhizae” as the key word in “HERB”, will produce the search result page as shown in Figure 10.1B. To discover what kind of compounds or herbs target a protein of interest, keying the protein name in “PROTEIN” will list which compound will target the protein directly or indirectly, and which herbs contain the compound.

 
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