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TCMs in Clinical Trials

An increasing number of TCM formulations are currently being tested in clinical trials and reported on www.ClinicalTrials.gov,45 a service of the US National Institutes of Health. www.ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. As of April 2016, there were >600 clinical

Diagram of proposed bakuchiol and ibandronate sodium in relation to the mevalonate pathway

Figure 11.4 Diagram of proposed bakuchiol and ibandronate sodium in relation to the mevalonate pathway. Ibandronate sodium is a bisphosphonate drug that inhibits Fpps in the melavonate pathway. From Meteor Nexus, bakuchiol can first undergo allylic hydroxylation and oxidation to yield a trisubstituted alkene metabolite. CYp2C19 and epoxide hydrolase can metabolize it to yield a mevalonic acid-like metabolite. This metabolite can then possibly act as a competitive inhibitor of mevalonic acid and stimulate the mevalonate pathway.

trials reported using different TCM formulations alone or in combination with Western therapeutics, involving >700 conditions.

 
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