Therapeutic Role of Glutamine in Inflammatory Bowel Disease

Hongyu Xue and Paul Wischmeyer

CONTENTS

  • 12.1 Introduction..........................................................................................................................165
  • 12.2 Multifactorial Nature of IBD Pathogenesis..........................................................................166
  • 12.3 Evidence for Nutritional Modulation of IBD by Glutamine.................................................167
  • 12.3.1 Clinical Evidence......................................................................................................167
  • 12.3.2 Preclinical Evidence from Experimental IBD Models.............................................171
  • 12.3.2.1 Improving Intestinal Barrier Integrity.......................................................171
  • 12.3.2.2 Regulating Intestinal Innate Immunity......................................................177
  • 12.3.2.3 Modulating Cytokine Balance and T Cell Polarization............................177
  • 12.3.2.4 Enhancing Intestinal Cytoprotective Heat Shock Response......................178
  • 12.4 Conclusions...........................................................................................................................179

References......................................................................................................................................179

 
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